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Gut hormone analogues and skeletal health in diabetes and obesity: evidence from preclinical models
24 avr. 2024 02:00 - SFR Icat
Diabetes mellitus and obesity are rapidly growing worldwide. Aside from metabolic disturbances, these two disorders also affect bone with a higher prevalence of bone fractures. In the last decade, a growingbody of evidence suggested that several gut hormones, including ghrelin, gastrin, glucose-dependent insulinotropic polypeptide (GIP), glucagon, and glucagon-like peptide-1 and 2 (GLP-1 and GLP-2, respectively) may affect bone physiology. Several gut hormone analogues have been developed for...
The associations of psychosocial work exposures with suicidal ideation in the national French SUMER study
24 avr. 2024 02:00 - SFR Icat
CONCLUSION: Psychosocial work exposures played a major role in suicidal ideation. More research may be needed to confirm our results, as suicidal ideation is an important warning signal for suicide prevention. More primary prevention towards the psychosocial work environment may be useful to reduce suicidal ideation at the workplace.
Synthetic cathinones in drug-facilitated sexual assault: A case report involving the novel generation substituted cathinone N-ethylpentedrone and a review of the literature
24 avr. 2024 02:00 - SFR Icat
The use of 3,4-methylenedioxymethamphetamine (MDMA) in drug-facilitated sexual assault (DFSA) is not uncommon. Indeed, the effects associated with the use of this substance may lead to disinhibition. Several synthetic cathinones, such as mephedrone or methylone, also possess marked entactogenic properties. This manuscript aims to (i) report a DFSA case involving a novel cathinone derivative, namely N-ethyl-pentedrone (NEPD) and (ii) review previously reported DFSA cases involving synthetic...
Literature highlights
23 avr. 2024 02:00 - SFR Icat
No abstract
Pediatric refractory chronic immune thrombocytopenia: Identification, patients' characteristics, and outcome
23 avr. 2024 02:00 - SFR Icat
Refractory chronic immune thrombocytopenia (r-cITP) is one of the most challenging situations in chronic immune thrombocytopenia (cITP). Pediatric r-cITP is inconsistently defined in literature, contributing to the scarcity of data. Moreover, no evidence is available to guide the choice of treatment. We compared seven definitions of r-cITP including five pediatric definitions in 886 patients with cITP (median [min-max] follow-up 5.3 [1.0-29.3] years). The pediatric definitions identified...
Author Correction: Fungal Colonization of the Airways of Patients with Cystic Fibrosis: The Role of the Environmental Reservoirs
22 avr. 2024 02:00 - SFR Icat
No abstract
Prevalence of major depressive disorder and post-traumatic stress disorder among first-time sleep center attendees
21 avr. 2024 02:00 - SFR Icat
CONCLUSION: Positive screening for MDD and PTSD are frequent in patients who attend sleep centers, especially amongst those presenting with insomnia. Nearly half of the patients with positive screening for MDD or PTSD were not receiving a dedicated pharmacological treatment. These figures emphasize systematic screening for psychiatric disorders in sleep clinics.
Translation into French and republication of: "Home treatment for patients with cancer-associated venous thromboembolism"
17 avr. 2024 02:00 - SFR Icat
Patients hospitalised with acute venous thromboembolism (VTE), and notably patients with pulmonary embolism, often remain in hospital for extended periods due to the perceived risk of complications. However, several studies have shown that home treatment of selected patients is feasible and safe, with a low incidence of adverse events. This may offer clear benefits for patients' quality of life, hospital planning and cost to the health service. Nonetheless, there is a need for a VTE...
Purplish granules as a cytological signature of cortical developmental disorders caused by pathogenic variants in WDR81
17 avr. 2024 02:00 - SFR Icat
No abstract
Adverse drug effect in the context of drug shortage: the CIRUPT prospective study from the French pharmacovigilance network
15 avr. 2024 02:00 - SFR Icat
CONCLUSIONS: From a pharmacovigilance point of view, a large diversity of anatomical therapeutic classes is involved and the risk related to drug shortages is not limited to drugs registered on 'major therapeutic interest or essential drug' lists. Information from health agencies is not sufficient to avoid the risks, and further strategies should be developed.
The overall fractions of coronary heart diseases and depression attributable to multiple dependent psychosocial work factors in Europe
14 avr. 2024 02:00 - SFR Icat
CONCLUSION: Our study showed that the overall fractions attributable to all studied psychosocial work factors were substantial especially for depression. These overall attributable fractions may be particularly useful to evaluate the burden and costs attributable to psychosocial work factors, and also to inform policies makers at European level.
The PAP-RES algorithm: Defining who, why and how to use positive airway pressure therapy for OSA
12 avr. 2024 02:00 - SFR Icat
Obstructive sleep apnea (OSA) is a common condition that is increasing in prevalence worldwide. Untreated OSA has a negative impact on health-related quality of life and is an independent risk factor for cardiovascular diseases. Despite available data suggesting that cardiovascular risk might differ according to clinical phenotypes and comorbidities, current approaches to OSA treatment usually take a "one size fits all" approach. Identification of cardiovascular vulnerability biomarkers and...
Dermatological manifestations in Costello syndrome: A prospective multicentric study of 31 HRAS-positive variant patients
10 avr. 2024 02:00 - SFR Icat
CONCLUSIONS AND RELEVANCE: This validated phenotypic characterization of a large number of patients with CS will allow future researchers to make a positive diagnosis, and to differentiate CS from CFCS and NS.
Cross-reactivity among and between macrolides, lincosamides, and streptogramins: Study on the French pharmacovigilance database
9 avr. 2024 02:00 - SFR Icat
CONCLUSION: This study highlights the possibility of cross-reactivity among and between MLSs. Dermatologists and allergologists managing patients with HSR to MLSs should be aware of a risk of cross-reactivity among the macrolides and between the different classes of MLS and to perform MLSs allergological testing before recommending an alternative antibiotic, especially in severe drug hypersensitivity from the MLS family.
Nanomedicines via the pulmonary route: a promising strategy to reach the target?
8 avr. 2024 02:00 - SFR Icat
Over the past decades, research on nanomedicines as innovative tools in combating complex pathologies has increased tenfold, spanning fields from infectiology and ophthalmology to oncology. This process has further accelerated since the introduction of SARS-CoV-2 vaccines. When it comes to human health, nano-objects are designed to protect, transport, and improve the solubility of compounds to allow the delivery of active ingredients on their targets. Nanomedicines can be administered by...