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Publications

Thiotepa-busulfan-fludarabine compared to clofarabine-based conditioning for haploidentical transplant with posttransplant cyclophosphamide in patients with myeloid malignancies: a retrospective study from the SFGM-TC
15 sept. 2025 02:00 - SFR Icat
The optimal reduced-intensity conditioning (RIC) regimen for haploidentical hematopoietic stem cells transplantation (haplo-HSCT) using post-transplant cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis has yet to be determined. Potential RIC regimen for haplo-HSCT in myeloid malignancies include Clofarabine-Baltimore (CloB) and TBF (thiotepa-busulfan-fludarabine). This multicenter retrospective study compared 297 adult patients receiving CloB (n = 59) or TBF (n = 238). The main...
Carpal tunnel syndrome and occupational co-exposure to biomechanical factors and neurotoxic chemicals using job-exposure matrices and self-reported exposure: Findings from the Constances cohort
15 sept. 2025 02:00 - SFR Icat
CONCLUSIONS: The study showed an association between self- reported CTS and co-exposure to biomechanical risk factors and chemicals. This finding should be confirmed using more objective case definition of CTS, e.g. carpal tunnel release surgery.
Promoting Job Leeway to ensure Sustainable Working Conditions for Cancer Survivors: we need to step up research efforts
15 sept. 2025 02:00 - SFR Icat
No abstract
<em>Staphylococcus lugdunensis</em> infective endocarditis: a multicentre international observational study
15 sept. 2025 02:00 - SFR Icat
CONCLUSION: This international multicentre study confirms that SLIE mimics Staphylococcus aureus IE, particularly with regard to aggressiveness, healthcare-related acquisition, complications, and mortality. Of note, all SL isolates were methicillin-susceptible.
Editorial
14 sept. 2025 02:00 - SFR Icat
No abstract
Treatment of febrile urinary tract infections caused by Enterococcus faecalis in male patients: a national survey among French infectiologists
12 sept. 2025 02:00 - SFR Icat
CONCLUSIONS: High-dose oral amoxicillin is the preferred treatment for FUTIEfM. Linezolid and fluoroquinolones (especially levofloxacin) are also used, though with less consensus. Therapeutic abstention appears appropriate in select clinical scenarios.
A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis
11 sept. 2025 02:00 - SFR Icat
CONCLUSION: Our study identifies an IFN-I signature in AAV, especially in MPA/MPO-AAV, underscoring its potential role in disease heterogeneity and kidney pathology. IFN-I emerges as a potential prognostic biomarker and therapeutic target in AAV, particularly for MPA. Further studies are needed to clarify its mechanisms and explore IFN-I modulation in clinical trials.
Development of a potential nano-based delivery system combining Colchicine-loaded lipid nanocapsules and BIOT-NFL-peptide to target glioblastoma
11 sept. 2025 02:00 - SFR Icat
Peptide conjugated-nanodrug is one of the most studied new treatment options in the field of cancer, including glioblastoma (GBM). This tumour, GBM, is a difficult to treat brain tumour mainly due to its location and the complexity of targeting tumour cells. A promising GBM-targeting peptide (NFL-TBS.40-63) is a cell penetrating peptide (CPP) that has previously demonstrated selectivity against GBM cells and also a capacity to damage their microtubule network at appropriate concentrations. Here,...
MetabOCT: a clinical trial looking for a metabolomic signature predicting the onset of Leber's hereditary optic neuropathy in healthy MtDNA mutations carriers
9 sept. 2025 02:00 - SFR Icat
CONCLUSION: Identifying pre-clinical biomarkers would open a window for clinical trials.
The MASC (Mobility of Arm SCore): A short and side-specific tool to assess functional impairment in patients with suspected thoracic outlet syndrome
8 sept. 2025 02:00 - SFR Icat
CONCLUSION: The MASC questionnaire demonstrated excellent feasibility and a strong correlation with the DASH and Quick-DASH questionnaires. It offers valuable insights into the laterality of the symptoms, in patients with suspected TOS. Future research should explore the sensitivity to changes of the MASC in the longitudinal follow-up of treated patients to validate these preliminary findings.
SREBP-mediated Signaling Restores Stem Cell Niche Properties in Human Lung Fibroblasts
8 sept. 2025 02:00 - SFR Icat
Emphysema is characterized by chronic alveolar destruction. Lipofibroblasts (LIF) are crucial in the stem cell niche surrounding alveolar type II (AT2) cells and may contribute to alveolar regeneration. We aim to determine whether emphysema is associated with LIF reduction and whether Sterol regulatory binding protein (SREBP) activation promotes LIF differentiation and fibroblast stem cell niche properties. We quantified LIF in the lungs of patients with emphysema compared to controls by...
Territorial and gender-linked risk factors for Buruli ulcer in Southern Benin: A case-control study using geographic and behavioral surveying
8 sept. 2025 02:00 - SFR Icat
CONCLUSION: The findings suggest that public health interventions need to consider gender, age, territorial features, and local agricultural practices. Furthermore, integrating geographical and spatial data into epidemiological studies offers valuable insights helping to prevent the spread of this neglected tropical disease.
Effects of Glucagon-Like Peptide-1 receptor agonists on bone health in people living with obesity
8 sept. 2025 02:00 - SFR Icat
Medications like liraglutide 3.0 mg daily (Saxenda®; Novo Nordisk) and semaglutide 2.4 mg weekly (Wegovy®; Novo Nordisk), which are glucagon-like peptide-1 receptor agonists (GLP-1Ra), have been sanctioned for prolonged weight management in people living with obesity (PwO). Although GLP-1 might enhance bone metabolism and quality, the impact of these receptor agonists on bone health remains uncertain and is the subject of this review. Data on bone health in the context of calorie restriction and...
Comorbidities in Mild WAS/XLT Require Lifelong Follow-Up and Consideration of Definitive Treatment
8 sept. 2025 02:00 - SFR Icat
Loss of function mutations in the gene encoding WASP (Wiskott-Aldrich syndrome protein) result in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia-XLT (WAS/XLT). The clinical severity of the disease can be assessed using the WAS clinical severity score. Typically, patients with a score of 3 or less at 2 years of age are considered to have mild WAS/XLT disease. However, patients with a low score in the first 2 years of life can still experience life-threatening complications, and...
Is Preoperative Anticoagulation in Nephrectomy with Caval Thrombectomy Necessary? A Multicenter Retrospective Cohort Study
8 sept. 2025 02:00 - SFR Icat
CONCLUSIONS AND CLINICAL IMPLICATIONS: The prescription of anticoagulation at the time of diagnosis of RCC with a CT does not appear to have any influence on the occurrence of thromboembolic events, while potentially increasing morbidity.