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EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis
23 oct. 2026 02:00 - SFR Icat
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase responsible for H3K27 trimethylation, has emerged as a potential therapeutic target in osteoarthritis (OA). However, its contribution to the multicellular mechanisms driving joint degeneration and pain remains poorly understood. Here, we investigated the effects of pharmacological EZH2 inhibition in a pain-relevant murine OA model and explored its cellular and molecular consequences across OA-associated cell populations. OA was...
Comparative Safety and Efficacy of Apixaban and Rivaroxaban During Extended Anticoagulation for Venous Thromboembolism: A Non-randomised Post Hoc Comparison Within the RENOVE Trial
23 oct. 2026 02:00 - SFR Icat
CONCLUSIONS: During extended anticoagulation, no difference in clinically relevant bleeding or recurrent VTE was observed between rivaroxaban and apixaban, although that non-randomised treatment allocation possibly influenced outcomes.
Beyond technical skills: women's expectations regarding the relational dimensions prior to gynecologic examinations
23 oct. 2026 02:00 - SFR Icat
CONCLUSION: Women consistently prioritized explicit and ongoing consent and sustained attention to their feelings. Privacy was also important, though more variable. These findings support the integration and structured assessment of non-technical competencies in training related to gynecologic examinations.
Onset of vitiligo during bimekizumab treatment for psoriasis
22 oct. 2026 02:00 - SFR Icat
Psoriasis is an inflammatory skin disorder characterized by epithelial hyperplasia and infiltration of inflammatory cells. Several immunological therapies have been developed for its treatment, including IL-17 inhibitors such as secukinumab, ixekizumab and bimekizumab. The safety profile of IL-17 inhibitors includes infectious diseases, gastrointestinal disorders, headaches, and cutaneous conditions such as eczema. Here, we report the first case of vitiligo, a depigmenting skin disorder...
A Recurrent 3'UTR Variant in CAPN3 Highlights the Diagnostic Impact of Non-Coding Variants in Limb-Girdle Muscular Dystrophies
22 oct. 2026 02:00 - SFR Icat
OBJECTIVE: A substantial proportion of individuals with suspected genetic conditions, including neuromuscular disorders, lack a definitive molecular diagnosis. Non-coding variants, particularly those in the 3' untranslated region (3´UTR), which regulate mRNA stability, translation, and localization, may underlie part of this gap. We investigated the clinical, genetic, and functional relevance of a novel 3'UTR variant in CAPN3 in individuals with persistent hyperCKemia, most of whom also...
Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia
20 oct. 2026 02:00 - SFR Icat
T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventional treatments. Herein, we report the antileukemic efficacy of anti-thymocyte globulin (ATG), a polyclonal cocktail of IgG enriched in antibodies directed against human thymocyte antigens. The treatment of preclinical...
Guidelines for the management of atrial fibrillation in adult patients admitted to an intensive care unit
19 oct. 2026 02:00 - SFR Icat
Most existing recommendations for atrial fibrillation are derived from cardiology settings. However, atrial fibrillation is also highly prevalent among patients admitted to intensive care units and is associated with adverse clinical outcomes. Therefore, its management in this specific context warrants dedicated guidance. To address this need, The French Intensive Care Society has developed formalized expert recommendations using the Grading of Recommendations Assessment, Development, and...
Estimating the eligible population for amyloid-targeting monoclonal antibody therapy in memory clinics: Application to lecanemab in France
14 oct. 2026 02:00 - SFR Icat
Lecanemab was the first amyloid-targeting monoclonal antibody approved by the European Commission for treating patients with mild cognitive impairment (MCI) and mild dementia due to Alzheimer's disease (AD). While this marketing authorization led to heterogeneous situations across European countries, France declined reimbursement, citing limited clinical benefit and concerns about the healthcare system's capacity to implement this new care pathway. This capacity depends directly on the number of...
Solriamfetol for residual sleepiness and its impact on continuous positive airway pressure adherence: A French database analysis
14 oct. 2026 02:00 - SFR Icat
CONCLUSION: We found no evidence that solriamfetol initiation was associated with reduced CPAP adherence.
Multimodal Profiling of Complement Expression and Association With Outcomes in ANCA-Associated Vasculitis With Glomerulonephritis
13 oct. 2026 02:00 - SFR Icat
CONCLUSION: AAV-GN displays a reproducible intrarenal complement-related transcriptional program, only weakly captured by serum levels or routine immunofluorescence, associated with renal severity and outcomes. These findings support prospective studies integrating tissue complement transcriptomics for stratification and therapeutic hypothesis generation.
Optimized RNA-seq workflow for routine diagnosis of mitochondrial diseases using aberrant expression analysis and phenotype-driven prioritization
12 oct. 2026 02:00 - SFR Icat
Mitochondrial diseases (MD) are the most common inherited metabolic disorders and show marked clinical and genetic heterogeneity. Despite widespread use of whole-exome (WES) and whole-genome sequencing (WGS), nearly half of patients remain without molecular diagnosis, partly due to difficulties in interpreting variants affecting RNA splicing or gene expression. RNA sequencing (RNA-seq) has shown promise in research settings, few studies have evaluated its feasibility in routine clinical...
Population pharmacokinetic modeling of idarubicin and idarubicinol in acute myeloid leukemia induction therapy: An ancillary study of the BIG-1 trial
12 oct. 2026 02:00 - SFR Icat
CONCLUSIONS: This study describes idarubicin and idarubicinol concentration-time profiles over the observed 24-h period in patients receiving AML induction therapy. Associations with body surface area and lymphocyte count require confirmation in an independent population. These findings provide a pharmacometric basis for future exposure-response investigations and prospective evaluation of model-informed therapeutic strategies approaches in AML.
Mouse Models of Aortic Pathologies: Deciphering Molecular and Cellular Mechanisms from Bench to Bedside
12 oct. 2026 02:00 - SFR Icat
CONCLUSIONS: By linking experimental findings to clinical perspectives, this review proposes a bench-to-bedside framework for the study of aortic disease. Integrating complementary experimental models with human-relevant systems may improve mechanistic understanding and support future diagnostic and therapeutic strategies innovation in aortic aneurysm and dissection.
Plasma Lipid Remodeling across Preclinical Burden, Disease Onset, and Early Motor Severity in Huntington's Disease
12 oct. 2026 02:00 - SFR Icat
CONCLUSIONS: HD is associated with coordinated plasma lipid remodeling across disease stages. Distinct lipid signatures characterize cumulative mutant huntingtin exposure, disease onset and motor progression, providing insights into the metabolic consequences of HD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Reference frame for Adult Brainstem gliomas
11 oct. 2026 02:00 - SFR Icat
Brainstem gliomas (BSG) are rare in adults (less than 2% of all gliomas) and generally have a better prognosis than pediatric BSG, although outcomes remain heterogeneous. Many other central nervous system (CNS) tumors, as well as nontumoral lesions, have been described as differential diagnoses and should be kept in mind. Each case should be examined by neurosurgeons from specialized centers to determine the most appropriate surgical approach among stereotactic biopsy, open biopsy, and tumor...
