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IL-34 is expressed in the pancreas and regulates local inflammation
24 juil. 2025 02:00 - SFR Icat
Interleukin-34, a ligand of CD115, controls Langerhans cells and microglia homeostasis and acts as regulatory cytokine. Here, we describe an unexpected role for IL-34 in metabolic homeostasis. We show that IL-34 is constitutively expressed by human β-cell and mouse islets of Langerhans. β-cell specific genetic invalidation of Il34 in mice (IL-34^(ΔPdx)) impaired glucose tolerance associated with increased inflammation in islets of Langerhans during aging. This phenotype was exacerbated when...
The dithiocarbamate pesticides maneb and mancozeb disturb the metabolism of lipids and xenobiotics in an in vitro model of metabolic dysfunction-associated steatotic liver disease
24 juil. 2025 02:00 - SFR Icat
Pesticides are increasingly recognized to be hepatotoxic, but less is known about their toxicity in metabolic dysfunction-associated steatotic liver disease (MASLD). Herein, differentiated HepaRG cells cultured for 2 weeks without (-FA) or with (+FA) a mixture of fatty acids were treated with different pesticides, including maneb and mancozeb, during the same period. While maneb and mancozeb did not induce neutral lipid accumulation in -FA-HepaRG cells, they worsened steatosis in +FA-HepaRG...
Contributions of betahydroxybutyrate (BHB) determination and thanatological biochemistry in postmortem diagnosis of ketoacidosis-related fatalities: two case reports
23 juil. 2025 02:00 - SFR Icat
Postmortem biochemical analyses are increasingly recognized as valuable tools to complement traditional forensic investigations, particularly in cases where the cause of death remains unclear after autopsy and toxicological analyses. Among these, the quantification of β-hydroxybutyrate (BHB) in femoral blood (FB) and/or vitreous humor (VH) has proven crucial in identifying fatal ketoacidosis. The authors report two forensic cases in which targeted biochemical markers (including BHB, vitreous...
Development of in-house ELISA for Scedosporium/Lomentospora serodiagnosis
22 juil. 2025 02:00 - SFR Icat
Scedosporium/Lomentospora species are ubiquitous molds that can cause deep-seated infections and allergic bronchopulmonary mycoses (ABPM). Serodiagnosis is currently performed by immunoprecipitation techniques (IP), which are time-consuming and lack reproducibility. In addition, as antigenic extracts for these fungi are not commercially available, many centers stopped performing this analysis. Therefore, there is a need for automated quantitative alternatives, such as ELISA. The aim of this...
Epidemiology of bone metastasis in France between 2009 and 2018
22 juil. 2025 02:00 - SFR Icat
Bone is the third most frequent metastatic site, and bone metastases (BM) are responsible for severe skeletal complications requiring dedicated care. There is no recent BM epidemiology data. This study aimed to describe incident BM patients in France between 2009 and 2018. We accessed the general sample of beneficiaries from the French health insurance reimbursement database. The algorithm identified new adult BM patients through the BM hospitalization code or through codes reflecting the onset...
Distribution reappraisal of peripheral T- and NK-cell lymphoma entities through the French Lymphopath network database
21 juil. 2025 02:00 - SFR Icat
No abstract
Drug-induced fluorosis: A study based on the national and international pharmacovigilance databases
20 juil. 2025 02:00 - SFR Icat
CONCLUSION: This study highlights pharmacovigilance signals suggesting a potential association between fluorosis and certain fluorinated compounds, particularly sodium fluoride, voriconazole, fluconazole, fludarabine and ciprofloxacin. Among these, only sodium fluoride and voriconazole include fluorosis in the summary of product characteristics. Clinicians should remain vigilant regarding this potential adverse drug reaction, especially with long-term use of these medications.
Transcranial Doppler goal-directed therapy after cardiac arrest (GOODYEAR): a feasibility study
18 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Implementing an individualised MAP management strategy guided by transcranial Doppler was challenging, with few patients eligible for evaluation. Still, transcranial Doppler identified a small group with persistent cerebral hypoperfusion despite optimised cerebral blood flow parameters. The study underscored technical and physiological limitations of this approach, which should inform the design and relevance of a larger trial to assess its clinical value.Trial registration:...
Pharmaceutical consultation as a harm reduction intervention in chemsex?
17 juil. 2025 02:00 - SFR Icat
No abstract
Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
16 juil. 2025 02:00 - SFR Icat
CONCLUSION: Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality. Prospective studies are warranted to confirm these results.
Anti-ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune-Mediated TTP
15 juil. 2025 02:00 - SFR Icat
Current triplet regimens associating therapeutic plasma exchange (TPE), immunosuppression with corticosteroids and rituximab, and caplacizumab have dramatically improved the outcome of immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, nearly half of the patients require extended caplacizumab treatment (i.e., > 30 days) due to persistent ADAMTS13 deficiency, raising cost and tolerance concerns. Therefore, we investigated whether anti-ADAMTS13 antibodies titer and their...
A Tunisian POLG mutation expands the clinical spectrum of POLG-related disorders
13 juil. 2025 02:00 - SFR Icat
Mitochondrial Neuro-Gastro-Intestinal Encephalopathy (MNGIE) is a rare and fatal mitochondrial disorder caused by biallelic mutations in the TYMP gene. In rare cases, it can be caused by pathogenic variants in the POLG gene, with a clinical presentation similar to that of TYMP-related MNGIE, except for the absence of leukoencephalopathy. Here we report the cases of six Tunisian patients presenting with a homogeneous clinical MNGIE-like phenotype, characterized by an early infantile onset. Key...
Effect of rifaximin in patients with severe cirrhosis and ascites: A randomized double-blind placebo-controlled clinical trial
13 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: RFX had no beneficial effect in terms of 12-month survival or incidence of complications of liver cirrhosis in patients with severe cirrhosis and low ascitic fluid protein levels. Improving patient adherence could reduce liver complications of cirrhosis.
Concerns arising from the calculation of the apnea-hypopnea index during CPAP-telemonitoring of patients with obstructive sleep apnea
12 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Our proof-of-concept study highlights inconsistencies in AHI(flow) calculations among CPAP manufacturers, raising concerns about patient care. Establishing standardized AHI(flow) calculation criteria is essential to ensuring accurate monitoring and optimal patient safety.
Cost-utility analysis of second line acromegaly treatment in France
11 juil. 2025 02:00 - SFR Icat
CONCLUSION: This model explores the cost-effectiveness of second-line pharmacological treatments of acromegaly accounting for the overall management recommended in France. Radiotherapy appears as a key therapeutic option allowing long-term remission of patients even after pharmacological treatment failure. This study is an additional tool for treatment choice including both a clinical and economic perspective.
