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Feasibility and Safety of a Ketogenic Diet During Systemic Therapy for Metastatic Renal Cell Carcinoma: Results from the Cetorein Pilot Study
12 juin 2026 02:00 - SFR Icat
CONCLUSIONS: KD is feasible and demonstrated an acceptable tolerability profile in selected mRCC patients, though long-term adherence is challenging. No conclusions regarding antitumor efficacy can be drawn from this small non-randomized pilot study. Future studies should evaluate shorter interventions and optimized dietary protocols in larger randomized trials.
Pembrolizumab-induced immediate hypersensitivity reactions
9 juin 2026 02:00 - SFR Icat
No abstract
Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine
9 juin 2026 02:00 - SFR Icat
CONCLUSIONS: In a long-term, resuscitated porcine model of acute subdural hematoma and hemorrhage, plasma NOx levels correlated with noradrenaline plasma levels, whereas mitochondrial respiration and other markers of radical formation or oxidative/nitrosative stress were unrelated to noradrenaline concentrations. β-adrenergic receptor expression was also unrelated to noradrenaline, while mitochondrial respiration was directly related to both the β(1)- and β(2)-adrenoceptor expression. Our...
A yeast-based platform for etoposide production via yatein bioconversion
8 juin 2026 02:00 - SFR Icat
Etoposide, a semisynthetic derivative of podophyllotoxin originally isolated from the rhizomes of mayapple (Podophyllum peltatum) and indian Podophyllum (P. hexandrum) plants, is one of the most powerful chemotherapeutic agents used to treat various types of solid tumors and blood malignancies. Despite its clinical importance, its supply is recurrently constrained due to a heavy reliance on plant extraction, where low natural precursor abundance and increasing climate-related pressures limit...
Descriptive Epidemiology and Prognosis of Pediatric Acute Leukemia in the Afro-Descendant Population of the French West Indies and French Guiana
4 juin 2026 02:00 - SFR Icat
CONCLUSION: This is the largest epidemiological study reported on childhood AL in an AD population and in the Caribbean/Latin America zone. Survival rates in our AD population were similar to those described in European and North American studies and much better than in the Caribbean and Latin American zone.
Prediction of bone marrow fibrosis from complete blood count in myeloproliferative neoplasms (FIBOM-AI): a multicentre machine learning model development and validation study
4 juin 2026 02:00 - SFR Icat
BACKGROUND: Bone marrow biopsy is essential for myeloproliferative neoplasms diagnosis, particularly for assessing bone marrow fibrosis. However, it is an invasive procedure that can be difficult to perform in some patients. This study aimed to develop an artificial intelligence (AI) model (FIBOM-AI) to predict grade 2-3 fibrosis using complete blood count (CBC) data and age.
COQ7-Related Neuropathy: Two New Cases and Review of the Literature
4 juin 2026 02:00 - SFR Icat
BACKGROUND AND AIMS: Biallelic variants in COQ7 have been associated with inherited neuropathy. COQ7 encodes a mitochondrial protein directly involved in coenzyme Q10 (CoQ10) biosynthesis.
Trace elements and vitamins status during pregnancy
1 juin 2026 02:00 - SFR Icat
Pregnancy is associated with physiological changes, particularly with regard to vitamins and trace elements. Crucial nutrients for optimal fetal development include vitamins B9 and B12, as well as minerals such as iron, zinc, copper, selenium, and iodine. Pregnant women with a history of bariatric surgery require special attention. Supplementation adjustment is mainly based on biological monitoring. Unfortunately, there are no validated reference values for the French population. The BIOMAT...
COXFA4L2 upregulation preserves residual cytochrome c oxidase activity in COXFA4-related Leigh-like encephalopathy
30 mai 2026 02:00 - SFR Icat
Primary mitochondrial diseases (PMDs) affect approximately 1 in 4300 individuals and cause early-onset neuromuscular and multisystem dysfunction with reduced lifespan. They result from pathogenic variants in mitochondrial or nuclear DNA that impair oxidative phosphorylation. Cytochrome c oxidase (COX; complex IV) deficiency is a well-established cause of PMD, leading to a broad spectrum of phenotypes. COXFA4 (cytochrome c oxidase subunit FA4), formerly NDUFA4, is a nuclear-encoded COX subunit,...
Anchoring ALS Prognosis: Neurofilament Light Chain Outperforms Inflammatory, Metabolic, and CNS Barrier Biomarkers in the METABALS Cohort
28 mai 2026 02:00 - SFR Icat
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder with marked biological heterogeneity. Despite extensive research, reliable prognostic biomarkers remain limited, with neurofilament light chain (NfL) being the only marker increasingly implemented in clinical practice. The objective of this study is to assess and compare the prognostic value of NfL, circulating markers of central nervous system (CNS) barrier dysfunction, inflammatory mediators,...
Long-term Outcome of Rheumatic Mitral Valve Surgery in Children From Low- and Middle-Income African Nations
28 mai 2026 02:00 - SFR Icat
BackgroundThere is limited information on rheumatic mitral valve surgery for children living in low- and middle-income African countries.Patients and methodsFrom 1/1/1998 to 1/1/2024, a total of 276 children <18 years of age, coming from Africa, underwent mitral valve (MV) surgery in France. The majority of the patients were in New York Heart Association (NYHA) class III. Mécénat Chirurgie Cardiaque operates in France on children with pediatric cardiac diseases. There were 28 patients who had...
Deciphering the role of the Sch9 serine/threonine kinase in <em>Scedosporium apiospermum</em>
27 mai 2026 02:00 - SFR Icat
Scedosporium apiospermum is an emerging opportunistic fungal pathogen, primarily affecting immunocompromised individuals. Notably, it ranks second among filamentous fungi infecting cystic fibrosis (CF) patients. Infections caused by S. apiospermum can range from localized infections to pulmonary colonization and invasive disseminated infections, often resulting in high mortality rates. This is largely attributed to the patient's clinical condition, limited diagnostic tools, and resistance to...
Technical recommendations from a large-scale French Delphi consensus: A step toward European harmonization of ctDNA analysis
26 mai 2026 02:00 - SFR Icat
CONCLUSIONS: By offering a robust, ready-to-implement framework that complements and refines existing international standards, this consensus paves the way for broader harmonization of ctDNA testing across Europe and beyond, ultimately strengthening confidence in liquid biopsy results for routine diagnostic and theragnostic applications in oncology.
Burst-Suppression EEG in Early Infantile Developmental and Epileptic Encephalopathies: Phenotype, Genotype, and Outcome
26 mai 2026 02:00 - SFR Icat
BACKGROUND AND OBJECTIVES: Developmental and epileptic encephalopathies (DEEs) with early burst-suppression EEG (EIDEE-BS) are among the most severe neonatal epileptic syndromes, typically presenting in the first months of life with refractory seizures and profound neurodevelopmental impairment. Although variants in the KCNQ2, STXBP1, and SCN2A genes are recognized as major causes, the full genetic spectrum remains uncertain. We aimed to delineate the electroclinical characteristics, genetic...
Kidney Outcomes With Rituximab Versus Cyclophosphamide in Crescentic ANCA-Associated Glomerulonephritis: Contextualizing Observational Findings
25 mai 2026 02:00 - SFR Icat
No abstract