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Publications

Development and Validation of the SDLD-Score: a Simplified Tool to Predict Successful Endoscopic Papillectomy in Ampullary Lesions
31 mai 2025 02:00 - SFR Icat
CONCLUSION: The SDLD score predicts incomplete resection in EP and aids treatment decisions.
Bi-allelic variants in TM2D3 cause a severe syndromic neurodevelopmental disorder associated with endoplasmic reticulum and mitochondrial abnormalities
31 mai 2025 02:00 - SFR Icat
We identified via exome sequencing bi-allelic variants in TM2D3 in four affected individuals from four unrelated families with overlapping clinical presentations, including microcephaly, severe global developmental delay with absent speech, autistic features, heart malformation, and dysmorphic facial features. TM2D3 encodes a transmembrane protein present in many tissues, with a higher abundance in the central nervous system, but little is known about its function and cell localization. Here, by...
Fourier Transform Infrared Imaging of Bone
31 mai 2025 02:00 - SFR Icat
Fourier transform infrared imaging (FTIRI) is a technique that can be used to analyze the material properties of bone using tissue sections. In this chapter, I describe the basic principles of FTIR and the methods for capturing and analyzing FTIR images in bone sections.
Bronchial Carcinoid Tumors in Children and Adolescents
31 mai 2025 02:00 - SFR Icat
CONCLUSION: BCTs are rare and frequently "typical," with a very favorable prognosis in children after an exclusively surgical strategy, even in LN+ cases.
A comparison of CDKN2A status in gliomas using different techniques: The loss of p16 as a surrogate marker
30 mai 2025 02:00 - SFR Icat
The presence of a CDKN2A homozygous deletion (HD) plays an important role in the diagnostic approach for neuropathologists and the clinical prognostic stratification of several CNS tumors. CDKN2A is located on chromosome 9p21 next to CDKN2B and MTAP and encodes for the protein p16. Various molecular diagnostics are routinely used for assessing the deletion. In this context, we studied a cohort of 40 adult-type gliomas to analyze the concordance of three different molecular techniques, ie, FISH,...
A Novel Function of Na<sub>V</sub> Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation
30 mai 2025 02:00 - SFR Icat
Endothelial cells (EC) play a pivotal role in vascular homeostasis. By sensing shear stress generated by blood flow, EC endorse vasculoprotection through mechanotransduction signaling pathways. Various ion channels are involved in mechanosignaling, and here, we investigated the endothelial voltage-gated Na^(+) channels (Na(V) channels), since their mechanosensitivity has been previously demonstrated in cardiomyocytes. First, we showed that EC from aorta (TeloHAEC) behave as EC from umbilical...
Childhood Humoral Immunity During and After COVID-19 Lockdowns
29 mai 2025 02:00 - SFR Icat
Our study, including serum from 3678 hospital inpatients and outpatients sampled before, during and after the COVID-19 lockdown periods, showed a significant decrease in overall IgG levels during the periods of sanitary restriction, particularly in children 3-10 years of age. Few months after the lifting of COVID-19 restrictions, immunoglobulin levels normalized. COVID-19 lockdowns may have induced a transient humoral immune gap.
Plasmonic behaviour of poly(2-ethyl-2-oxazoline)-coated gold nanoparticles for sensing and temperature-control applications
29 mai 2025 02:00 - SFR Icat
Gold nanoparticles functionalized with xanthate-poly(2-ethyl-2-oxazoline) (PEtOx-AuNPs) were investigated as thermoresponsive hybrid nanomaterials with tunable optical and thermal properties. The PEtOx-AuNPs exhibited changes in surface plasmon resonance (SPR) and amplified Surface-Enhanced Raman Scattering (SERS) signals during the reversible lower critical solution temperature (LCST) transition of the PEtOx ligand. The effect of the PEtOx coating on the photophysical properties of AuNPs,...
Oncogenomic profiling in infant-toddler T-ALL identifies NKX2 family genes as drivers linked to favorable outcomes
28 mai 2025 02:00 - SFR Icat
T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive hematological malignancy primarily affecting adolescents and young adults and is scarce in infants and toddlers under age 3. Unlike B-ALL, T-ALL in this young population remains poorly characterized due to limited data and lacks evidence-based guidelines to help clinicians determine the optimal treatment approach. In this study, we conducted a comprehensive genetic analysis of infant/toddler T-ALL cases from a French national...
Integrating pharmacogenetics in sport medicine: enhancing treatment precision and preventing unintentional doping violation
27 mai 2025 02:00 - SFR Icat
No abstract
An assessment of the effects of simulation training on management of postpartum hemorrhage: short- and long-term impact on knowledge retention, skills and teamwork in the Democratic Republic of Congo
26 mai 2025 02:00 - SFR Icat
CONCLUSION: Simulation-based training has a part to play in training healthcare providers to manage post-partum hemorrhage. Training should be repeated after a period of 6 months to enhance knowledge and skill retention.
Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction
26 mai 2025 02:00 - SFR Icat
CONCLUSIONS: From these results, CLU protects the heart from inflammatory injury in AMI and this cardioprotection is due at least in part to its ability to neutralise extracellular histones released from the damaged tissue.
Glioneuronal tumors PATZ1-fused: clinico-molecular and DNA methylation signatures for a variety of morphological and radiological profiles
24 mai 2025 02:00 - SFR Icat
The neuroepithelial tumor, PATZ1-fused (NET-PATZ1), has been recently isolated as a distinct methylation class by DNA-methylation profiling and is characterized by recurrent PATZ1 fusions, in association with the EWSR1 or MN1 genes and a chromosome 22 chromothripsis. The clinical phenotype is mainly pediatric and features circumscribed supratentorial tumors. However, the histopathology is vastly heterogeneous (glial, glioneuronal, sarcomatous, multiphenotypic) and a cell of origin has not yet...
Pain Intensity after Robotic-assisted Urological Surgery: the PAIROU study An International Prospective Cohort Study
23 mai 2025 02:00 - SFR Icat
CONCLUSION: This large cohort study demonstrates that patients experience low pain scores and require low opioids after robotic-assisted urological surgery when commonly used multimodal analgesia protocols are administered.
Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function
23 mai 2025 02:00 - SFR Icat
Intercellular and inter-organ communication systems are vital for tissue homeostasis and disease development, utilizing soluble bioactive molecules for signaling. The field of extracellular vesicle (EV) biology has rapidly expanded in recent decades, highlighting EVs as effective bioactive nanovectors for cell-to-cell communication in various physiological and pathological contexts. Numerous studies indicate that adipocyte-derived EVs are crucial components of the adipose secretome, playing a...