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Assessing Laboratory Capacity for Diagnosis of Fungal Infections in France: A Multicentre survey within the SINFONI Network
14 mai 2026 02:00 - SFR Icat
Invasive fungal diseases are life-threatening complications, particularly in immunocompromised patients, and require rapid and accurate diagnosis to improve clinical outcomes. Although major advances in fungal diagnostics that includes antigen detection, molecular assays, and MALDI-TOF mass spectrometry, have transformed diagnostic strategies, access to these tools remains heterogeneous. In France, national data on diagnostic capacities for invasive fungal diseases have been lacking. Using the...
Immediate post-traumatic pseudoaneurysm of the external carotid artery following condylar fracture: case report
13 mai 2026 02:00 - SFR Icat
CONCLUSION: This case emphasizes the need to consider vascular injury in acute condylar trauma. Prompt vascular imaging and endovascular embolization are essential and potentially lifesaving.
Peripheral neurological involvement due to Bartonella henselae in an immunocompetent adolescent: a case report and literature review
13 mai 2026 02:00 - SFR Icat
This report describes a rare case of post-infectious meningoradiculitis caused by Bartonella henselae in a healthy 17-year-old male. The patient presented with bilateral peripheral facial palsy, paresthesia and absent deep tendon reflexes, following axillary lymphadenopathy related to cat scratches. Lumbar puncture showed lymphocytic pleocytosis, and serological results showed high titers of both IgG and IgM for Bartonella henselae. Electroneuromyography revealed prolonged F waves. Treatment...
Blinatumomab Consolidation for High-Risk Ph-negative B-cell Acute Lymphoblastic Leukemia: the GRAALL-2014/B-QUEST Study
13 mai 2026 02:00 - SFR Icat
Intensified chemotherapy regimens have improved outcomes in adults with Philadelphia chromosome (Ph)-negative B-cell acute lymphoblastic leukemia (B-ALL), yet relapse remains a major cause of treatment failure and death. Blinatumomab, a CD19×CD3 bispecific T-cell engager, has demonstrated marked activity in relapsed, measurable residual disease (MRD)-positive B-ALL, and in frontline consolidation for MRD-negative patients. The phase 2 GRAALL-2014/B-QUEST sub-study (NCT02617004) evaluated the...
High-Resolution Imaging Reveals Mitochondrial Protein Imbalance in Sperm of Oligoasthenospermic Men
11 mai 2026 02:00 - SFR Icat
Male infertility accounts for nearly half of global infertility cases and is often linked to poor sperm quality, such as oligospermia, asthenospermia, and teratospermia. Although the exact mechanisms remain unclear, mitochondria, which are critical for ATP production and reactive oxygen species generation during fertilization, are increasingly recognized as key players in male infertility but remain underexplored. ATP synthesis relies on respiratory chain complexes that establish a proton...
RNA-based precision medicine in glioblastoma driven by oncogenic gene fusions
11 mai 2026 02:00 - SFR Icat
Glioblastoma, the most common primary central nervous system tumor, is the leading cause of death in neuro-oncology. Gene fusions, caused by chromosomal rearrangements, may act as drivers of tumorigenesis in glioblastoma. These fusions result from the juxtaposition of two genes, leading to the production of a chimeric protein and, in most cases, constitutive activation of a tyrosine kinase receptor. Despite the use of tyrosine kinase inhibitors to block the oncogenic activity of gene fusions,...
Similar Long-Term Effectiveness With Different Approaches of Unilateral Hypoglossal Nerve Stimulation For OSA
10 mai 2026 02:00 - SFR Icat
No abstract
Innovation in antifungal therapy
9 mai 2026 02:00 - SFR Icat
With a steady increase in the number of at-risk patients, invasive fungal infections now represent a significant public health problem. These infections, caused by major pathogens such as Aspergillus, Candida, Cryptococcus, and Pneumocystis, affect increasingly diverse patient profiles, primarily immunocompromised individuals, with mortality rates often exceeding 50%. Managing these patients remains challenging, as very few systemic antifungals are currently available, compounded by major...
Genomic newborn screening as a paradigm shift in rare disease management, with emphasis on endocrine conditions
8 mai 2026 02:00 - SFR Icat
CONCLUSION: Genomic NBS is transforming rare disease management, including endocrine diseases, by enabling earlier diagnosis, precision care, and coordinated professional and family-based interventions, marking a paradigm shift in population health.
Time to diagnosis and treatment of obstructive sleep apnoea using mandibular jaw movement monitoring versus polysomnography: an open-label, multicentre, randomised, controlled trial
8 mai 2026 02:00 - SFR Icat
BACKGROUND: Obstructive sleep apnoea (OSA) is often underdiagnosed, highlighting the need for scalable diagnostic alternatives. The SUNSAS study compared a new device for at-home diagnosis of OSA (artificial intelligence [AI]-supported analysis of mandibular jaw movements [MJM]) with polysomnography (PSG) for time to diagnosis and treatment, and patient-reported outcomes.
Study protocol FRENCH-ARRIVE: labor induction in low-risk nulliparous women at 39 weeks of gestation to reduce cesarean births: a randomized trial of induction versus expectant management in France
7 mai 2026 02:00 - SFR Icat
BACKGROUND: The ARRIVE trial showed that elective induction of labor at 39 weeks for low-risk nulliparous women compared to expectant management reduced cesarean delivery rates with a nonsignificant trend toward decreased perinatal morbidity. However, the generalizability of these findings to other health care systems and obstetric contexts outside of the United States remains uncertain.
A dataset of patients with isolated and syndromic optic neuropathies linked to RTN4IP1 genetic variants
7 mai 2026 02:00 - SFR Icat
Biallelic pathogenic variants of the Reticulon 4 interacting protein 1 (RTN4IP1) gene are responsible for optic atrophy, either isolated or associated with ataxia, mental retardation, and seizures. They are identified as a cause of hereditary optic neuropathy in 7% of patients diagnosed before the age of 20. We have built a dataset for this gene by collating all the clinical cases available in the literature, and unpublished patients diagnosed at our centre, using standard nomenclature to...
Cyclin-dependent kinase inhibitors and kidney injury: Analysis of the French pharmacovigilance database
7 mai 2026 02:00 - SFR Icat
CONCLUSIONS: CDK4/6 inhibitors may cause functional and true renal impairment, ranging from mild, reversible creatinine increases to severe acute kidney injury. When performed, renal biopsy showed ATN and TIN. Close monitoring of renal function including cystatine-C based GFR evaluation and characterization of renal injury are essential to optimize patient safety.
Primary cilia disruption reprograms extracellular vesicle signaling in endothelial dysfunction and cardiovascular disease
7 mai 2026 02:00 - SFR Icat
AIMS: Primary cilia disruption profoundly alters vascular integrity. Extracellular vesicles (EVs) released during ciliary decapitation have emerged as potential mediators of these effects, yet their functional contribution remains unclear. Here, we investigated the effects of extracellular vesicles (EVs) released by deciliated endothelial cells on endothelial responses and evaluated their clinical relevance.
ESA VIVALDI (1 & 2) Campaigns: Sex-Specific Bone Responses to Dry Immersion-Induced Unloading
7 mai 2026 02:00 - SFR Icat
Skeletal unloading during microgravity rapidly disrupts bone and metabolic homeostasis, yet sex-specific physiological responses remain poorly characterised. Dry immersion (DI), a ground-based analogue of microgravity, provides a model to investigate early determinants of unloading-induced bone deconditioning. We assessed sex differences in biochemical markers of bone and energy metabolism during two 5-day European Space Agency DI campaigns (VIVALDI 1 and 2) involving healthy males (n=19) and...