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Transcranial Doppler goal-directed therapy after cardiac arrest (GOODYEAR): a feasibility study
18 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Implementing an individualised MAP management strategy guided by transcranial Doppler was challenging, with few patients eligible for evaluation. Still, transcranial Doppler identified a small group with persistent cerebral hypoperfusion despite optimised cerebral blood flow parameters. The study underscored technical and physiological limitations of this approach, which should inform the design and relevance of a larger trial to assess its clinical value.Trial registration:...
Pharmaceutical consultation as a harm reduction intervention in chemsex?
17 juil. 2025 02:00 - SFR Icat
No abstract
Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant: a retrospective multicenter study
16 juil. 2025 02:00 - SFR Icat
CONCLUSION: Temporary suspension of immunosuppressive drugs may reduce the risk of ICU-acquired infections, with a true uncertainty on day-90 mortality. Prospective studies are warranted to confirm these results.
Anti-ADAMTS13 Antibodies Trajectory is Associated With ADAMTS13 Recovery in Immune-Mediated TTP
15 juil. 2025 02:00 - SFR Icat
Current triplet regimens associating therapeutic plasma exchange (TPE), immunosuppression with corticosteroids and rituximab, and caplacizumab have dramatically improved the outcome of immune-mediated thrombotic thrombocytopenic purpura (iTTP). However, nearly half of the patients require extended caplacizumab treatment (i.e., > 30 days) due to persistent ADAMTS13 deficiency, raising cost and tolerance concerns. Therefore, we investigated whether anti-ADAMTS13 antibodies titer and their...
A Tunisian POLG mutation expands the clinical spectrum of POLG-related disorders
13 juil. 2025 02:00 - SFR Icat
Mitochondrial Neuro-Gastro-Intestinal Encephalopathy (MNGIE) is a rare and fatal mitochondrial disorder caused by biallelic mutations in the TYMP gene. In rare cases, it can be caused by pathogenic variants in the POLG gene, with a clinical presentation similar to that of TYMP-related MNGIE, except for the absence of leukoencephalopathy. Here we report the cases of six Tunisian patients presenting with a homogeneous clinical MNGIE-like phenotype, characterized by an early infantile onset. Key...
Effect of rifaximin in patients with severe cirrhosis and ascites: A randomized double-blind placebo-controlled clinical trial
13 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: RFX had no beneficial effect in terms of 12-month survival or incidence of complications of liver cirrhosis in patients with severe cirrhosis and low ascitic fluid protein levels. Improving patient adherence could reduce liver complications of cirrhosis.
Concerns arising from the calculation of the apnea-hypopnea index during CPAP-telemonitoring of patients with obstructive sleep apnea
12 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Our proof-of-concept study highlights inconsistencies in AHI(flow) calculations among CPAP manufacturers, raising concerns about patient care. Establishing standardized AHI(flow) calculation criteria is essential to ensuring accurate monitoring and optimal patient safety.
Cost-utility analysis of second line acromegaly treatment in France
11 juil. 2025 02:00 - SFR Icat
CONCLUSION: This model explores the cost-effectiveness of second-line pharmacological treatments of acromegaly accounting for the overall management recommended in France. Radiotherapy appears as a key therapeutic option allowing long-term remission of patients even after pharmacological treatment failure. This study is an additional tool for treatment choice including both a clinical and economic perspective.
Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomised controlled trial
10 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Regional anaesthesia by parasternal intercostal plane blocks after sternotomy did not improve QoR at 24 h compared with standard care.
Derivation and Validation of a COPD-specific Pulmonary Embolism Diagnostic Strategy
10 juil. 2025 02:00 - SFR Icat
Diagnosing pulmonary embolism (PE) in patients with chronic obstructive pulmonary disease (COPD) exacerbation is challenging due to similarities in clinical symptoms. The aim of this study was to evaluate predictors of PE and to derive and validate a COPD-specific PE diagnostic strategy.A post-hoc analysis of the PEP trial, a prospective multicenter study of patients with COPD hospitalized with acutely worsening respiratory symptoms, was conducted. The outcome predicted was PE at admission....
Extensive and delayed necrosis of a free flap following subtotal glossectomy and adjuvant radiotherapy
10 juil. 2025 02:00 - SFR Icat
Oral tongue squamous cell carcinoma is the most common malignancy of the oral cavity. Treatment of this tumor is based on surgical removal with a centimeter margin, which can be combined with radiotherapy. This case report details a late necrosis of an anterolateral thigh flap used for oncological reconstruction of a subtotal glossectomy requiring comprehensive management. A 61-year-old patient, with no medical history, was treated for a large squamous cell carcinoma with subtotal glossectomy...
Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis
9 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: Transcriptomic analysis of kidney biopsies in AAV-GN identified 150 differentially expressed immune-related genes and led to the development of a 12-gene signature that correlated strongly with kidney survival, outperforming established histological classifications.
DNA methylation profiling or the future of neuro-oncology?
7 juil. 2025 02:00 - SFR Icat
Diagnosis of central nervous system tumors is based on the histopathologic features and molecular alterations. For certain entities, this histomolecular diagnosis now includes DNA methylation profiles. Methylation profiles reflect the cell of origin and epigenetic modifications that occur during tumorigenesis and may help classify central nervous system tumors via artificial intelligence algorithms. This powerful approach to tumor classification has revolutionized the field of neuro-oncology,...
How to Assess Fungal Contamination of Indoor Air in Dwellings of Patients with Cystic Fibrosis?
6 juil. 2025 02:00 - SFR Icat
Chronic colonization by filamentous fungi in patients with cystic fibrosis (pwCF) is linked to declines in lung function and quality of life. To better assess indoor mold exposure, 23 French dwellings of pwCF from CF care centers in Normandy and Maine & Loire, France were visited. Bioaerosols collected using Coriolis® µ and Coriolis® compact biocollectors and dust were cultured on four different media: Potato Dextrose Agar (PDA), Malt Extract Agar (MEA), Sabouraud Chloramphenicol Gentamicin...
Screening, prevalence, and risk factors for secondary localization during candidemia in intensive care unit patients: the French CandidICU multicenter study
5 juil. 2025 02:00 - SFR Icat
CONCLUSIONS: In this cohort, 76·4% of ICU patients with candidemia were screened for SL and at least one SL was diagnosed in 21·8%. The severity at ICU admission and duration of positive blood cultures were identified as independent risk factors for SL, whereas age and Candida glabrata infection were protective. Finally, the screening and occurrence of SL were associated with significant changes in the management of patients.