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Thromboinflammation is associated with high thrombotic risk in patients with newly diagnosed myeloproliferative neoplasms
23 déc. 2025 01:00 - SFR Icat
Thrombotic risk assessment is crucial in newly diagnosed essential thrombocythemia (ET) and polycythemia vera (PV) patients to guide cytoreductive therapy. We assessed whether thromboinflammation biomarkers would be good candidates to improve thrombosis risk stratification. We prospectively enrolled 394 newly diagnosed, cytoreductive therapy-naïve, ET and PV patients. We measured seven plasma biomarkers of neutrophil, monocyte, platelet, and endothelial activation, including NET markers, and...
Successful treatment with Rezafungin following Micafungin for relapsing Rasamsonia argillacea species complex pneumonia in a patient with bronchiectasis: a case report
23 déc. 2025 01:00 - SFR Icat
Rasamsonia argillacea species complex are emerging opportunistic molds increasingly reported in patients with chronic lung disease. We describe a 69-year-old woman with bronchiectasis who developed relapsing R. aegroticola pneumonia. After transient improvement with micafungin, relapse occurred, and antifungal therapy was switched to rezafungin, a novel echinocandin with a prolonged half-life and front-loaded pharmacokinetics. Three months of treatment led to clinical and radiological...
Effect of Baseline Dialysis and Plasma Exchange on Renal Prognosis in Patients With Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
22 déc. 2025 01:00 - SFR Icat
CONCLUSION: MPO-ANCA, need for dialysis, and high histological renal risk score at baseline were associated with the 1-year composite end point of death or ESKD. Almost half of the patients on dialysis at baseline were off dialysis at 1 year, with a better prognosis in those who had received PLEX.
Trifloxystrobin induces oxidative stress-dependent activation of the OMA1-DELE1-HRI integrated stress response leading to apoptosis in human neuroblastoma cells
21 déc. 2025 01:00 - SFR Icat
Trifloxystrobin (TFX), a potent inhibitor of complex III in the mitochondrial respiratory chain, is a widely used strobilurin fungicide whose neurotoxic mechanisms remain poorly defined. This study investigated the molecular pathways underlying TFX-induced toxicity in human SH-SY5Y neuronal-like neuroblastoma cells, with particular emphasis on oxidative stress, mitochondrial dysfunction, and activation of the Integrated Stress Response (ISR). TFX exposure (24 h) exhibited an IC(50) of...
Cerebral diffusion of posaconazole in an experimental model of disseminated scedosporiosis
20 déc. 2025 01:00 - SFR Icat
CONCLUSIONS: These findings suggest increased permeability of the blood-brain-barrier, possibly related to changes in IL or gene expression levels in the brain. Infection and the resulting inflammation should therefore be considered for therapeutic drug monitoring, especially in cases of cerebral infection.
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
19 déc. 2025 01:00 - SFR Icat
Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. We performed a CRISPR-Cas9 knockout screen focused on ubiquitin E3 ligases and related proteins with the DNA topoisomerase I inhibitor camptothecin. This led us to establish that MAEA, a core subunit of the CTLH E3 ligase complex, is a critical regulator of homologous recombination and the replication stress response....
Human resources framework to obtain JACIE accreditation (SFGM-TC)
19 déc. 2025 01:00 - SFR Icat
International organizations FACT and the Joint Accreditation Committee ISCT-Europe & EBMT (JACIE) have developed a reference framework that provides a safe structure for the management of cellular therapies. This framework (FACT-JACIE v8.2) is organized according to a quality management approach. During the annual workshops of the Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC), we aimed to enable medical directors to build an effective human resource management...
Hypoglossal nerve stimulation in the treatment of obstructive sleep apnea: Update on French practices and position paper of the SFRMS, SPLF and SFORL sleep medicine work-group
19 déc. 2025 01:00 - SFR Icat
CONCLUSION: This new alternative treatment in France should be proposed for symptomatic patients with failure of CPAP or MAD, rigorously screened in multidisciplinary centers.
The first year of treatment with selumetinib for NF1-related plexiform neurofibroma is medically challenging in real-life settings
18 déc. 2025 01:00 - SFR Icat
BACKGROUND: Plexiform neurofibromas (PNFs) occur in 20-50 % of NF1 patients and can alter skin appearance and/or invade adjacent structures. These tumors grow rapidly in childhood, leading to significant morbidity. Surgical treatment is recommended as first-line therapy, but complete resection is not always possible, and the risk of recurrence is high. Selumetinib is a selective inhibitor of MEK protein kinases that has been shown to reduce PNF tumor volume. It has been approved as monotherapy...
Skn7 Regulates Response to Oxidative Stress in the Opportunistic Fungi Scedosporium apiospermum
17 déc. 2025 01:00 - SFR Icat
The ability to survive and militate oxidative stress has received particular attention as one of the virulence factors of human pathogens. While underlying mechanisms have been largely studied for some fungi, those employed by the rising opportunistic fungal threat Scedosporium spp. are not fully understood yet. Previous transcriptomic studies helped identify the main oxidative stress-induced antioxidant enzymes in S. apiospermum. We therefore wanted to gain insight into regulators governing...
Assessment of social cognition impairments in patients with amyotrophic lateral sclerosis: How can it be improved? A systematic review
16 déc. 2025 01:00 - SFR Icat
CONCLUSION: Social cognition is increasingly recognized as a key non-motor domain affected in ALS. However, current assessment tools may lack the sensitivity and ecological validity needed to capture real-life deficits. The implementation of dynamic, multimodal assessments such as real-life social interaction tests or tests like the Movie Assessment for Social Cognition (MASC) could improve detection and guide clinical interventions but remain to be validated for ALS patients.
A systematic review of the valuable roles of community pharmacists in colorectal cancer screening across various countries
16 déc. 2025 01:00 - SFR Icat
CONCLUSION: Pharmacists contributions appeared valuable across healthcare systems, when appropriately recognized, supported, and remunerated.
Endocarditis risk stratification with scores: what about reproducibility? The case of NOVA and DENOVA scores for Enterococcus faecalis bacteremia
13 déc. 2025 01:00 - SFR Icat
CONCLUSION: The reproducibility of these scores is limited, especially near critical thresholds, highlighting the need to complement scoring tools with clinical judgment in EfB.
Fréquences d’exposition aux principaux facteurs de risque biomécaniques d’usure professionnelle chez les femmes et les hommes dans la cohorte CONSTANCES
9 déc. 2025 01:00 - SFR Icat
No abstract
Tailoring fungi for controlling vector-borne infectious diseases
9 déc. 2025 01:00 - SFR Icat
Vector-borne infectious diseases remain a burden within the intertropical belt, and developing holistic vector-control strategies poses a significant challenge. Recently, Tang and colleagues engineered an entomopathogenic fungus that attracts and kills mosquitoes by emitting a woody-scented compound.