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Publications

Clinical characteristics and treatments of imported loiasis patients with microfilaraemia diagnosed in France, 2000-2022
24 avr. 2026 02:00 - SFR Icat
CONCLUSION: In France, loiasis treatment is inconsistent and frequently relies on inadequate options, including IVM monotherapy, which lacks therapeutic efficacy, and carries safety concerns. Our findings highlight real-world practices and indicates that better training is needed for practitioners treating patients with loiasis.
Modeling of End-tidal to transcutaneous oxygen pressure difference dynamics during cardio-pulmonary exercise testing: a retrospective study
23 avr. 2026 02:00 - SFR Icat
CONCLUSION: Continuous PtcO₂ monitoring enables detailed characterization of exercise-induced alveolar-arterial gas exchange in healthy individuals. ET-tcDO₂ follows a polynomial of the third-degree during CPET. The combined use of PETO₂ and PtcO₂ may offer a simple, non-invasive approach for assessing alveolar-arterial gas exchange in routine clinical practice that should be further investigated.
Integration of circulating tumor DNA profiling in the risk stratification of classical Hodgkin lymphoma in children, adolescents, and young adults
22 avr. 2026 02:00 - SFR Icat
This study aimed to define the potential role of circulating tumor DNA (ctDNA) in children, adolescents, and young adults (CAYA) with classical Hodgkin lymphoma (cHL). This prospective trial was conducted in France between 2019 and 2023 and recruited CAYA patients (≤25 years old) with a new diagnosis of cHL. Patients were treated according to the EuroNet-PHL-C2 trial (EudraCT: 2012-004053-88), and plasma ctDNA evaluations were performed at diagnosis, after two cycles of chemotherapy, and in case...
Predictive factors for injection interval extension after switching to faricimab in neovascular AMD: The FAR WEST multicentre study
21 avr. 2026 02:00 - SFR Icat
CONCLUSION: Switching to faricimab allowed significantly extending the recurrence-free injection interval, decreasing the proportion of exudative patients and reducing the therapeutic burden in nAMD patients. Further studies are needed to determine the most appropriate switching modalities and which patients actually require an induction phase.
Spread of extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) in the community living spaces of patients identified as ESBL-E carriers: impact of the housing density in an African context
18 avr. 2026 02:00 - SFR Icat
CONCLUSIONS: In the area under study, there is significant colonization of both human and animals by ESBL-E, and a major diversity among the isolated strains. Our geographic analysis suggests a human impact on animal colonization, even though the results do not support direct transmission. Concurrently, genomic analysis suggests the possibility of dissemination over significant distances.
TRXR2, a thioredoxin reductase-encoding gene, contributes to protection against the oxidative stress and virulence in Scedosporium apiospermum
18 avr. 2026 02:00 - SFR Icat
Scedosporium apiospermum has received an increased attention over the past decades, especially because of its low susceptibility to current antifungals and its clinical relevance in cystic fibrosis. Nevertheless, little is still known about its pathogenic mechanisms. During the inflammatory reaction, macrophages and neutrophils release antimicrobial compounds, especially reactive oxygen species (ROS). To cope with ROS, pathogens have developed various strategies, including synthesis of some...
Cerebrospinal fluid in the context of headaches with decreased visual acuity
17 avr. 2026 02:00 - SFR Icat
No abstract
Meningeal syndrome in an immunocompromised patient
17 avr. 2026 02:00 - SFR Icat
No abstract
Using a Physiology Virtual Laboratory to Explore Vascular Reactivity: Feedback from Undergraduate Biology Students in France
17 avr. 2026 02:00 - SFR Icat
The evolution of European and French regulations regarding animal experimentation in higher education has prompted universities to develop alternative methods to animal testing. The University of Angers (France) has created a web-based virtual lab (VL) called ExAVir (https://labua.univ-angers.fr/Projets/exavir/) designed to simulate practical lab work in animal physiology and pharmacology. In this study, we evaluated the perception of ExAVir among third-year undergraduate physiology students at...
Limited Sampling Strategies to Estimate the Exposition of Different Lipid Nanocaspules
17 avr. 2026 02:00 - SFR Icat
CONCLUSIONS: This approach reduces the number of blood samples by 70% while maintaining high accuracy. The main limitations concern its generalizability to other formulations or species, which would require additional validation.
Dapagliflozin for cardiorenal protection after intensive care unit discharge: a protocol for a randomised controlled trial evaluating dapagliflozin at ICU discharge for cardiorenal protection (DAPA-ICU)
16 avr. 2026 02:00 - SFR Icat
INTRODUCTION: Patients discharged from intensive care units (ICUs) are at high risk of adverse long-term outcomes including cardiovascular and/or renal events and a 1-year mortality of approximately 22%. Plasma biomarkers measured at ICU discharge have demonstrated strong prognostic value, with elevated cardiac or renal biomarkers identifying patients at particularly high risk of poor outcomes. Sodium-glucose cotransporter 2 inhibitors are now widely recognised for their cardioprotective and...
The orphan receptor GPR84 drives inflammation in Buruli ulcer development
15 avr. 2026 02:00 - SFR Icat
Inflammatory responses can be of critical importance in determining both the course and outcome of infectious diseases. Buruli ulcer, a neglected tropical disease caused by Mycobacterium ulcerans (M. ulcerans), has been reported to induce both immunosuppressive and proinflammatory responses in the skin. Here, we found that genetic inactivation of the orphan receptor GPR84 in mice leads to spontaneous healing of ulcerative lesions, recapitulating the rare spontaneous healing observed in human...
sPaRT2 - Minimally Invasive Partial versus Radical Nephrectomy for cT2 Renal Cell Carcinoma: A National Matched-Pair Analysis (UroCCR 235)
10 avr. 2026 02:00 - SFR Icat
CONCLUSION: RAPN is a safe and functionally superior alternative to RN for selected patients with cT2 RCC. While associated with higher perioperative morbidity, these risks are acceptable in expert centers and offset by long-term nephron-sparing benefits.
Re: 'Clinical utility of the DENOVA score for predicting infective endocarditis in Enterococcus faecalis bacteremia' by Varisco et al
9 avr. 2026 02:00 - SFR Icat
No abstract
Clinical and Genetic Spectrum of ACO2-Linked Dominant Optic Atrophy
9 avr. 2026 02:00 - SFR Icat
CONCLUSIONS AND RELEVANCE: Results of this case series reveal the high clinical heterogeneity among patients with ACO2-related DOA and demonstrated that some of these patients can also exhibit retinal abnormalities. In addition, there was a deletion of an entire ACO2 exon, emphasizing the potential importance of searching for large genomic rearrangements in patients without a molecular diagnosis. These findings support further studies to explain clinical variability, as no genotype-phenotype...