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Assessment of simulation-based therapeutic education in pseudoxanthoma elasticum patients
13 janv. 2026 01:00 - SFR Icat
No abstract
REACT-PXE: a consensus on diagnosis and future research concerning pseudoxanthoma elasticum (PXE)
10 janv. 2026 01:00 - SFR Icat
Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder described more than 150 years ago in which calcification and fragmentation of the elastic fibers result in a variety of symptoms which differ greatly in presentation and severity between patients. The diagnosis of PXE can still be made in many patients based on clinical presentation. However, in the advent of genetic screening that followed upon the identification of the first causal gene, ABCC6, milder cases of PXE or patients...
Epidemiology of Amyotrophic Lateral Sclerosis in the Pays de la Loire, France: A 20-Year Study from a Centralized Diagnostic Center
10 janv. 2026 01:00 - SFR Icat
CONCLUSION: This 20-year retrospective study provides the first epidemiological data on ALS in western France. The incidence and clinical features are consistent with national and European data. The identification of spatial and occupational clusters underlines the importance of continued regional surveillance and of prospective, registry-based studies to clarify environmental and occupational risk factors for ALS.
Blood-borne sphingosine 1-phosphate maintains vascular resistance, blood pressure, and cardiac function in mice
9 janv. 2026 01:00 - SFR Icat
Sphingosine 1-phosphate (S1P) is a bioactive lipid that circulates in plasma bound to high-density lipoproteins (HDL) and albumin. Circulating S1P levels correlate positively with systolic blood pressure (BP) in hypertension and negatively with severity in septic shock and with left ventricular function in heart disease. In mice, isolated deficiency in HDL-S1P and endothelial cell S1P receptor (R)-1 both trigger hypertension, supporting an essential role for HDL-S1P in endothelial function....
Clinical biology and artificial intelligence: Objectives of the SFBC Workgroup
9 janv. 2026 01:00 - SFR Icat
The arrival of AI in medical biology is inevitable, and in many ways these tools are already in use in our laboratories. Given this observation, it was determined that it was imperative for the French Society of Clinical Biology to offer a set of resources to enable medical biologists to master these new tools by understanding their complexity and the risks inherent in using such powerful but obscure tools. The "Clinical Biology and Artificial Intelligence" workgroup was created to meet this...
Assessment of Infectious Risk Factors in Benign Prostatic Hyperplasia Surgery: Results of the French Multicenter TOCUS Study
9 janv. 2026 01:00 - SFR Icat
CONCLUSIONS: This study did not find an association between the surgical technique used for BPH treatment and postoperative infectious risk. However, ABU, whether monomicrobial, bimicrobial, or polymicrobial, was strongly associated with postoperative infectious complications, with no impact of preoperative antibiotic therapy or antibiotic prophylaxis.
Dystonia-deafness syndrome 1 caused by ACTB p.(Arg183Trp) de novo variant: one novel case extending the phenotypic spectrum
8 janv. 2026 01:00 - SFR Icat
Dystonia-deafness syndrome 1 (DDS1) is a rare disorder caused by the p.(Arg183Trp) heterozygous variant in ACTB. Patients present with congenital/early-onset sensorineural deafness, then childhood/adult-onset generalized dystonia. We describe a 38 y.o patient with additional features, including brain malformations: corpus callosum and vermis hypodysplasia. These novel features expand the clinical spectrum of DDS1, and suggests an overlap with ACTB-related Baraitser-Winter syndrome. Furthermore,...
Ethnicity affects relapse-free survival in immune-mediated thrombotic thrombocytopenic purpura
8 janv. 2026 01:00 - SFR Icat
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is caused by a severe, antibody-mediated deficiency of ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motifs, 13th member) activity. The B-cell depleting agent rituximab is effective in restoring ADAMTS13 activity and therefore preventing relapses. However, the risk of relapse appears heterogeneous among patients, although the underlying causes are elusive. Preliminary reports suggested that African ancestry could be...
Self-assemblies from prodrugs composed of antimicrobial peptides: a revolution in local lung cancer treatment, with microbiota as a main actor
7 janv. 2026 01:00 - SFR Icat
Human microbiota is now recognized as a fundamental organ of the body. In its healthy state, it fulfills essential local and systemic functions, whereas dysbiosis disrupts these roles and can contribute to disease. Although numerous studies have examined the relationship between microbiota and cancer, often revealing conflicting mechanisms and outcomes, this work has focused almost exclusively on the gut, leaving the lung microbiota largely unexplored. In this project, a ferrocifen compound was...
Genetic diversity of Usher syndrome in Moroccan patients
7 janv. 2026 01:00 - SFR Icat
No abstract
Viral clearance and escape during therapy of COVID-19 outpatients: A prospective cohort study
7 janv. 2026 01:00 - SFR Icat
The efficacy of neutralizing SARS-CoV-2 monoclonal antibodies (mAbs) in preventing severe COVID-19 has been hindered by the diversity of viral strains and the complexity of patient populations. In this prospective cohort study, we used regression analyses to identify virological, immunological, and clinical factors associated with viral clearance and emergence of escape mutations. We included 114 mainly immunocompromised high-risk patients with mild-to-moderate COVID-19 who received mAbs or...
Corrigendum to 'Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells' [International Journal of Pharmaceutics: X 4 (2022) 100129]
7 janv. 2026 01:00 - SFR Icat
[This corrects the article DOI: 10.1016/j.ijpx.2022.100129.].
Who are the healthcare professionals involved in interprofessional team meetings in French multidisciplinary primary care centres? A quantitative analysis of eight centres
6 janv. 2026 01:00 - SFR Icat
CONCLUSIONS: Depending on the MPCC, the professionals involved in ITM vary widely, with the nurse-GP pair at the centre. The relative absence of certain professionals needs to be analysed in order to encourage interprofessional working.
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis
6 janv. 2026 01:00 - SFR Icat
CONCLUSIONS AND RELEVANCE: The age-adjusted D-dimer cutoff may safely rule out DVT and was associated with a larger number of patients in whom DVT could be effectively ruled out.
Selective Use of Thromboaspiration in STEMI: CMR Evidence Against Routine Practice
3 janv. 2026 01:00 - SFR Icat
CONCLUSION: TA during primary PCI was associated with increased occurrence and extent of MVO, particularly in patients with delayed reperfusion or non-occlusive thrombus. These findings reinforce current ESC guidelines against routine TA use and suggest that its application should be restricted to carefully selected patients.
