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Publications

Comment on: Use of teicoplanin monotherapy for the treatment of enterococcal infective endocarditis: a retrospective and comparative study at a referral centre
8 mai 2025 02:00 - SFR Icat
No abstract
Health Promotion in Primary Care: Lessons from the 6<sup>th</sup> Francophone Primary Care Group symposium
8 mai 2025 02:00 - SFR Icat
Integrating health promotion into primary care is critical to transforming healthcare systems. While many promising initiatives exist, their sustainability and scalability remain key challenges. Major barriers include limited institutional recognition, lack of understanding by policymakers, weak evaluation culture, and undervaluation in public policies. Local solutions are essential, but require systemic support, including cross-sectoral collaboration, funding, and training. A paradigm shift is...
Distribution of amiodarone between lipid nanocapsules and residual micelles: Tangential flow filtration as a purification method and its impact on cytotoxicity
6 mai 2025 02:00 - SFR Icat
Amiodarone (AMD) is an anti-arrhythmic drug prescribed for the treatment of atrial fibrillation. Despite its efficiency, AMD causes several extracardiac side effects due to its highly lipophilic nature, limiting its clinical use. Lipid nanocapsules (LNCs) are a promising approach for encapsulating AMD and altering its whole-body biodistribution. It has been established that during the phase inversion composition process to prepare LNCs loaded with AMD (LNC-AMD), some residual micelles will also...
Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial
5 mai 2025 02:00 - SFR Icat
CONCLUSIONS: Maintaining very low tidal volume ventilation with positive end-expiratory pressure during CPB did not reduce postoperative infections at 28 days compared to when mechanical ventilation was stopped during CPB. An unexpectedly higher use of antibiotics was observed when ventilation was maintained.
Editorial
4 mai 2025 02:00 - SFR Icat
No abstract
High prevalence of chronic endometritis in women diagnosed with hydrosalpinx before in vitro fertilization treatment
4 mai 2025 02:00 - SFR Icat
CONCLUSIONS: There is a significant increase in the prevalence of CE in women with hydrosalpinx undergoing IVF, whether the hydrosalpinx was unilateral or bilateral.
Impact of shared HLA determinants between patient and losing cord blood unit on relapse after double cord blood transplantation
2 mai 2025 02:00 - SFR Icat
During double umbilical cord blood transplant (DUCBT), the winning unit (WU) rejects the losing unit (LU) due to WU T-cells directed against the LU mismatched HLA. This immune response might protect against relapse, especially when the patient and LU (PT-LU) share the same mismatch with the WU. To validate this hypothesis, a retrospective Eurocord study, conducted on 383 DUCBT, focused on post-transplant relapse and HLA mismatches between PT-LU and the WU. A PT-LU shared HLA-A mismatch with the...
Systematic vitamin K antagonist reversal with prothrombin complex concentrate in patients with mild traumatic brain injury: randomized controlled trial
2 mai 2025 02:00 - SFR Icat
CONCLUSION: In patients with recent mild-TBI receiving a VKA, systematic prompt reversal with 4f-PCC did not statistically significantly reduce ICH rate at 24 h. However, the study was prematurely stopped and does not exclude a clinically relevant benefit of the strategy tested.
Assessment of the Prognostic and Predictive Values of the Deficient Mismatch Repair Phenotype in Patients Treated with Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
30 avr. 2025 02:00 - SFR Icat
CONCLUSIONS AND CLINICAL IMPLICATIONS: We observed that the dMMR phenotype was associated with favorable pathological characteristics and prognosis in UTUC patients, despite conferring decreased sensitivity to AC and lower PD-L1 or PD-1 expression.
Identification of Hepatic-like EPO as a Cause of Polycythemia
30 avr. 2025 02:00 - SFR Icat
CONCLUSIONS: We found that secondary erythrocytosis can be related to variants in EPO that lead to the production of hepatic-like EPO with an atypical glycosylation pattern and increased activity. (Funded by Région des Pays de la Loire and others; ClinicalTrials.gov number, NCT03957863.).
Current landscape and future directions of targeted-alpha-therapy for glioblastoma treatment
30 avr. 2025 02:00 - SFR Icat
Glioblastoma (GB) is the most aggressive malignancy of the central nervous system. Despite two decades of intensive research since the establishment of the standard of care, emerging strategies have yet to produce consistent satisfactory outcomes. Because of its specific localisation and intricate characteristics, GB is a uniquely regulated solid tumour with a strong resistance to therapy. Advances in targeted radionuclide therapy (TRT), particularly with the introduction of a-emitting...
Kidney Transplantation Improves Survival in Lupus Nephritis With End-Stage Kidney Disease
30 avr. 2025 02:00 - SFR Icat
CONCLUSION: Compared with patients who remain on dialysis, KT is associated with improved survival in patients with LN-ESKD. Early evaluation of transplant eligibility and timely referral to transplant centers are crucial for optimizing outcomes.
The copper ionophore disulfiram improves mitochondrial function in various yeast and human cellular models of mitochondrial diseases
29 avr. 2025 02:00 - SFR Icat
The copper ionophore disulfiram (DSF) is commonly used to treat chronic alcoholism and has potential anti-cancer activity. Using a yeast-based screening assay of FDA-approved compounds, DSF was herein identified for its ability to improve oxidative phosphorylation-dependent growth of various yeast models of mitochondrial diseases caused by a wide range of defects in ATP synthase, complexes III and IV, cardiolipin remodeling, maintenance and translation of the mitochondrial genome. This compound...
Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma
28 avr. 2025 02:00 - SFR Icat
Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood-brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptide and the chemotherapeutic agent doxorubicin. This platform integrates targeted delivery and therapeutic action to enhance efficacy while minimising off-target effects. Our findings reveal superior cellular...
Epidemiology and prediction of non-targeted bacteria by the filmarray pneumonia plus panel in culture-positive ventilator-associated pneumonia: a retrospective multicentre analysis
28 avr. 2025 02:00 - SFR Icat
CONCLUSIONS: A significant rate of culture-positive VAP cases with non-targeted bacteria was observed in this study, raising concerns about the interpretation of FAPPP results. Only positive FAPPP results may assist clinicians in the early personalization of antibiotic therapy for VAP.