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Publications

Longitudinal change in FEV<sub>1</sub> in adults with cystic fibrosis treated with elexacaftor-tezacaftor-ivacaftor in France: a prospective observational study
11 nov. 2026 01:00 - SFR Icat
BACKGROUND: Without cystic fibrosis transmembrane conductance regulator (CFTR) modulators, cystic fibrosis is associated with an accelerated decline in percent predicted FEV(1) (ppFEV(1)) of approximately 1·5% per year. Although treatment with elexacaftor-tezacaftor-ivacaftor (ETI) initially increases ppFEV(1), little is known about its subsequent effect on ppFEV(1) decline. Recent analyses of the extension phases of the phase 3 ETI pivotal studies found no evidence of ppFEV(1) decline over 4...
Reinforced strategies versus standard pneumococcal vaccination regimen in patients with ANCA-associated vasculitides receiving rituximab therapy: A Multicenter Randomized Controlled Trial
10 nov. 2026 01:00 - SFR Icat
CONCLUSIONS: In AAV patients receiving rituximab, reinforced pneumococcal vaccination strategies improved humoral immunogenicity compared with the standard regimen (ClinicalTrials.gov Identifier: NCT03069703).
Osteoid Definition and Bone Formation
10 nov. 2026 01:00 - SFR Icat
Bone formation begins with the establishment of a tissue called osteoid, traditionally described as unmineralized. Despite extensive research on bone, this primary tissue remains surprisingly understudied, as reflected by the very limited number of reviews dedicated to it. Current understanding largely relies on data from diverse experimental models, ranging from human bone to calcified chicken tendon, and spanning different stages of development (from embryo to adult), although bone structure...
Engineering yeast for anticancer drug biosynthesis
9 nov. 2026 01:00 - SFR Icat
No abstract
Occupation, Job Retention and Pseudoxanthoma Elasticum (PXE)
9 nov. 2026 01:00 - SFR Icat
CONCLUSIONS: PXE can substantially affect occupational functioning, predominantly through visual impairment. Further studies are needed to evaluate the effectiveness of job retention strategies in patients with PXE.
Variability of lipoprotein(a) levels in patients with acute myocardial infarction between admission, discharge, and follow-up
8 nov. 2026 01:00 - SFR Icat
CONCLUSION: Although the median Lp(a) level remained stable between admission and follow-up, one-third of AMI patients shifted within Lp(a) categories over time. Pending external validation, an exploratory two-step strategy based on Lp(a) measurement at discharge, followed by repeat testing in patients with Lp(a) >37 mg/dL, showed a misclassification rate below 1% for identifying patients potentially needing intervention.
The CAST technique: A novel capture-assisted Safari tracking maneuver for radial pigtail repositioning after TAVI
7 nov. 2026 01:00 - SFR Icat
CONCLUSION: The CAST technique is a simple, reproducible, and equipment-free maneuver that can overcome selected difficulties encountered with radial access during minimalist TAVI. It may reduce repeated catheter and guidewire manipulation and avoid the need for additional femoral access.
Metabolomics Reveals Multiple Metabolic Alterations and Biomarkers of Disease Severity in Facioscapulohumeral Muscle Dystrophy
7 nov. 2026 01:00 - SFR Icat
CONCLUSIONS: These findings highlight systemic metabolic disturbances already detectable in mild-to-moderate stages of facioscapulohumeral muscular dystrophy, identifying creatinine and ADMA as promising biomarkers of disease severity, and expand current knowledge of disease pathophysiology.
Real-world use of extracorporeal photopheresis for BK polyomavirus infection after kidney transplantation: results from the French multicenter registry
6 nov. 2026 01:00 - SFR Icat
CONCLUSION: This study represents the largest published multicenter real-world cohort of KT recipients treated with ECP for BKPyV infection. ECP combined with immunosuppression minimization was associated with favorable virological and immunological outcomes and an excellent safety profile. Although this observational study cannot establish the efficacy of ECP, it provides a comprehensive description of current ECP practice for BKPyV infection and supports the rationale for prospective...
Correction: Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
5 nov. 2026 01:00 - SFR Icat
No abstract
Long-term outcomes and predictors of response to rituximab in anti-MAG neuropathy: a multicenter real-world study
5 nov. 2026 01:00 - SFR Icat
CONCLUSION: In this large multicenter real-world cohort, more than one third of patients with anti-MAG neuropathy experienced long-term functional improvement following RTX monotherapy. Shorter disease duration, lower monoclonal IgM levels, and an induction regimen of 1 g on days 1 and 15 were associated with good response to treatment.
Correction: Scleromyxedema-Associated Myopathy and Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS) as manifestations of Monoclonal Gammopathy of Clinical Significance (MGCS): a disease spectrum between autophagy dysfunction and inflammation
3 nov. 2026 01:00 - SFR Icat
No abstract
Isoform-specific Modulation of Drug Metabolism in a Fatality Involving Olanzapine Overexposure: Inflammation-Induced Phenoconversion as a Mechanistic Framework
2 nov. 2026 01:00 - SFR Icat
CONCLUSIONS: The selective accumulation of olanzapine, contrasted with preserved exposure to drugs predominantly metabolized by CYP3A4/2D6/alternative UGT isoforms, supports isoform-specific metabolic inhibition. CYP1A2 was the most plausible target of suppression. Although the impact of inflammation on UGT activity is less well characterized and appears isoform- and substrate-dependent, the selective modulation of UGT1A4 cannot be excluded. Overall, this case emphasizes that inflammation may...
Eltrombopag during induction chemotherapy in older patients with newly diagnosed acute myeloid leukemia is safe and reduces platelet transfusion requirements: The EPAG-2015 French Innovative Leukemia Organization phase 2 randomized trial
31 oct. 2026 01:00 - SFR Icat
CONCLUSIONS: This study failed to demonstrate a survival advantage after eltrombopag addition, at variance with previous reports, but shows that initiating eltrombopag after chemotherapy washout is feasible and safe, and resulted in a decreased need for platelet transfusions.
Contribution of DNA methylation profiling to the diagnosis of primary central nervous system tumors
29 oct. 2026 01:00 - SFR Icat
CONCLUSION: In 71% cases with CS>0.9, histomolecular and methylation-based diagnoses were concordant. In more than 80% of these cases, methylation profiling provided additional information. In only 5.8% cases did methylation results lead to a change in the final diagnosis. DNA methylation profiling is a valuable tool for confirming and refining CNS tumor diagnosis. However, its results must always be interpreted in conjunction with clinical, radiological, histopathological, and other molecular...