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Publications

"Goofballing": An Emerging Threat With Clinical Challenges-A Short Communication
19 juin 2025 02:00 - SFR Icat
CONCLUSIONS: This case highlights the diagnostic challenges associated with the "goofball" phenomenon. The coadministration of methamphetamine and heroin can lead to severe atypical toxicological symptoms. Health care providers should be aware of this emerging practice to ensure rapid diagnosis and appropriate management. Public health initiatives should focus on harm reduction strategies to mitigate associated risks.
A molecular signature predicts hematologic evolution in polycythemia vera patients
18 juin 2025 02:00 - SFR Icat
Genetic analyses have been included in scoring systems to improve the prognostic stratification of hematologic malignancies. Until now, molecular risk scores have not been included into the practical management of patients with polycythemia vera (PV). In this work, we studied 439 PV patients recruited from 15 French centers and described their mutational landscape using high-throughput sequencing. We detected an additional mutation in 53.3% of patients, 22.7% of them having 2 or more mutations....
Morphine and metformin impact immunotherapy benefit in patients with NSCLC: Results of the real-world study IFCT-1502 CLINIVO-SNDS
18 juin 2025 02:00 - SFR Icat
CONCLUSION: Our study confirmed the negative impact of morphine and high-dose corticosteroids on immunotherapy efficacy regardless of poor prognostic factors related to disease aggressiveness. On the other hand, our findings suggested a positive impact of metformin on immunotherapy outcomes.
Pre-emptive TIPS for gastric variceal bleeding in patients with cirrhosis (GAVAPROSEC): an open-label randomised clinical trial
15 juin 2025 02:00 - SFR Icat
BACKGROUND: In patients with cirrhosis, variceal glue obliteration is recommended for the treatment of acute fundal variceal bleeding, and for the prevention of rebleeding in combination with non-selective β blockers (NSBB). We evaluated the efficacy of pre-emptive transjugular intrahepatic portosystemic shunt (p-TIPS) in this setting.
A DIA-MS-based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients
15 juin 2025 02:00 - SFR Icat
No blood-based protein biomarkers are currently available for routine clinical use to determine the prognosis of patients with glioblastoma (GB). We performed data-independent acquisition mass spectrometry (DIA-MS)-based proteomics on 96 presurgical serum samples from patients with GB and 30 serum samples from healthy controls to identify such markers. Among the 622 serum proteins differentially expressed between the GB and control groups, 191 had a |log(2)(fold change)| ≥ 0.58 and an area under...
NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development
14 juin 2025 02:00 - SFR Icat
CONCLUSIONS: Our data demonstrate that NLRP3-inflammasome, carried by EVs, is actively involved in vascular inflammation and atherosclerosis development in MetS. We highlight NLRP3 carried by EVs as potential biomarker and target for potential therapeutic strategies of atherosclerosis-related diseases leading to major adverse cardiovascular events.
Aside: Interview with Pr Mathilde Duchesne
14 juin 2025 02:00 - SFR Icat
No abstract
Contemporary Epidemiology, Management, and In-Hospital Outcomes of Acute Myocarditis: The Prospective Multicenter MyocarditIRM Study
14 juin 2025 02:00 - SFR Icat
CONCLUSIONS: This prospective cohort represents the largest AM database worldwide. Although the recruitment process likely led to a selection of patients with lower risk AM, 8% experienced in-hospital complications, the major prognosis factor being severity criteria upon admission. (French National Observatory Tracking Viral Myocarditis: Mortality, Cardiovascular Events, Sequels on (Magnetic Resonance Imaging) MRI; NCT02717143).
Overall Survival After Allogeneic Transplantation in Advanced Cutaneous T-Cell Lymphomas (CUTALLO): A Propensity Score-Matched Controlled Prospective Study
13 juin 2025 02:00 - SFR Icat
Cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and sometimes fatal diseases. Patients presenting with advanced-stage CTCL usually exhibit poor long-term survival outcomes. Only very few treatments have improved progression-free survival (PFS) in advanced CTCL, and no treatment has increased overall survival (OS). In 2023, the results of the CUTALLO trial supported the hypothesis that hematopoietic stem-cell transplantation (HSCT) was associated with significantly longer PFS as...
Hydrocortisone and arginine vasopressin in post-resuscitation shock: the HYVAPRESS trial
12 juin 2025 02:00 - SFR Icat
BACKGROUND: Acute circulatory failure after successfull resuscitation of cardiac arrest remains challenging and multifactorial. As the main driver of early mortality after restoration of spontaneous circulation, its therapeutic management essentially relies on fluids administration and vasopressive support using noradrenaline. Data also support the potential impact of a hormonal defect in this setting. Steroids substitution as well as argini-vasopressin treatment should be evaluated in these...
Bone graft in bilateral mandibular sagittal split osteotomy: the current state of practice in France
10 juin 2025 02:00 - SFR Icat
CONCLUSION: This survey shows the diversity of practices in France regarding the use of grafting in BSSO. Further studies are needed to investigate prospectively the utility of such procedures.
Kidney Transplantation Improves Survival in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides With End-Stage Kidney Disease
9 juin 2025 02:00 - SFR Icat
CONCLUSION: KT is associated with a significant survival benefit in waitlisted patients with AAV-ESKD compared with waiting on dialysis. These findings emphasize the importance of timely transplant evaluation and improved access to KT for this population.
Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation
6 juin 2025 02:00 - SFR Icat
No abstract
Valve-in-valve transcatheter aortic valve replacement versus redo surgical aortic valve replacement in patients with degenerated aortic bioprostheses: Three-year death rates and haemodynamic performance
5 juin 2025 02:00 - SFR Icat
CONCLUSIONS: ViV-TAVR and Re-SAVR had similar mortality and haemodynamic outcomes at 3 years, including in patients with small bioprostheses where self-expandable valves yielded the best results.
Optimization of insulin management during postprandial and post-absorptive exercise in adults with type 1 diabetes: DiabraAlgo effectiveness in real life ?
5 juin 2025 02:00 - SFR Icat
CONCLUSION: DiabraAlgo enables an effective adaptation of insulin levels during exercise, promoting their immediate applicability for individuals with T1D.