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Publications

Metabolic engineering in <em>Nicotiana benthamiana</em>
28 nov. 2025 01:00 - SFR Icat
Plants can produce compounds with extraordinary chemical structures and a wide range of applications in the treatment of human diseases. The biosynthesis of such compounds in plants is often complex and limited to specific tissues and specialized cells, resulting in low yields. Unlike many medicinal plants, Nicotiana benthamiana is easy to grow and is amenable to genetic manipulation. Indeed, many metabolic pathways for valuable medicinal compounds have been elucidated and reconstructed in N....
The WELSH tool, is valid and sensitive to changes during the assessment of walking ability in severe anemia of pregnancy
27 nov. 2025 01:00 - SFR Icat
The Walking Estimated Limitation Stated by History (WELSH) questionnaire is a pictorial tool for assessing functional walking ability accessible to people with little or no schooling . Its use in severe anemia of pregnancy have not yet been studied. We aimed to evaluate the correlation of the WELSH score to hemoglobin level (Hb) and the sensitivity of the WELSH tool to hemoglobin changes in pregnant women. We performed a prospective study among pregnant women with documented severe biological...
Investigating the neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies
26 nov. 2025 01:00 - SFR Icat
Neurodevelopmental proteasomopathies are a group of disorders caused by variants in proteasome subunit genes, that disrupt protein homeostasis and brain development through poorly characterized mechanisms. Here, we report 26 distinct variants in PSMC5, encoding the AAA⁺ ATPase subunit PSMC5/RPT6, in individuals with syndromic neurodevelopmental conditions. Combining genetic, multi-omics and biochemical approaches across cellular models and Drosophila, we unveil the essential role of proteasomes...
Evaluation of dermatology care pathways incorporating store-and-forward telemedicine: A retrospective cohort study
26 nov. 2025 01:00 - SFR Icat
No abstract
Local recurrence after R0 partial nephrectomy for RCC: insights from a large multicenter cohort (PREPARE study - UroCCR 140)
26 nov. 2025 01:00 - SFR Icat
No abstract
Characterization of <em>Hottentotta judaicus</em> Scorpion Venom: Toxic Effects and Neurobehavioral Modulation in Insect Models
26 nov. 2025 01:00 - SFR Icat
Scorpion venom is a rich source of diverse bioactive molecules with medicinal importance. While the venoms of many Buthidae scorpions have been extensively studied for their toxicity and therapeutic potential, Hottentotta judaicus scorpion venom (HjSV) remains poorly explored. In this study, using LC-ESI-MS, we show that HjSV has a complex composition. We find that HjSV has no significant cytotoxic effects on three human cancer cell lines, even at concentrations of up to 1000 µg/mL. However, it...
The contribution of comparative genomics to health geography research: A case study on the identification of sites at which M. ulcerans contamination occurs in Benin
25 nov. 2025 01:00 - SFR Icat
We report here a significant advance in research into Buruli ulcer, a skin disease caused by an environmental bacterium (Mycobacterium ulcerans). We demonstrate the utility of crossed analyses of comparative genomics and geographic data to improve our understanding of the spatial dynamics of this disease and to identify potential sites of contamination with greater precision. An analysis of patient isolates from the endemic region Ouémé-Plateau (Benin) led to the detection, of a spatial...
Memory Function and Huntington's Disease: A Systematic Review
25 nov. 2025 01:00 - SFR Icat
This systematic review aimed to identify preserved and impaired memory processes in Huntington's disease (HD), with consideration of disease stage and the specific memory subsystems assessed. A systematic search was conducted in PubMed, ScienceDirect, and Google Scholar up to March 11, 2025. Eligible studies had to be peer-reviewed, had to involve participants aged 18 or older, had to include patients with genetically or clinically confirmed HD, and had to be published in English or French. Risk...
Janus kinase and calcineurin-inhibitor combination in anti-MDA5 dermatomyositis: No significant survival benefit but reassuring safety profile
24 nov. 2025 01:00 - SFR Icat
CONCLUSION: JAK-CNI showed a similar outcome to other immunosuppressive combinations. However, as the study included the most severe cases, the potential benefit of early JAK-CNI introduction in less severe forms cannot be dismissed, as suggested by the nonsignificant trend in non-ICU patients. Future studies are needed to clarify the optimal timing and patient selection for JAK-CNI therapy in anti-MDA5 DM.
Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism
22 nov. 2025 01:00 - SFR Icat
BCL-xL promotes cell survival by binding BH3-only initiators through its hydrophobic groove. Combining resonance energy transfer assays and molecular dynamics simulations, we unravel that membrane anchoring of BCL-xL via its tail anchor selectively advantages binding to membrane-anchored PUMA initiator over BH3 mimetic ligands of the groove. This is due to the combined allosteric effect on BH3-in-groove binding of BCL-xL and PUMA tail anchors. Moreover, doubly anchored PUMA / BCL-xL complexes...
Clinical Presentation and Mid-Term Results of Mitral Valve Surgery for Calcified Mitral Valve Disease - The MITRACURE registry
22 nov. 2025 01:00 - SFR Icat
CONCLUSION: CMVD defines a high-risk surgical population with substantial baseline cardiovascular morbidity and markedly elevated postoperative mortality and complication rates that were substantially underestimated by EuroSCORE II emphasizing the need for refined risk prediction models and individualized management strategies in this subset of patients.
Obstructive sleep apnoea syndrome and recurrent vasovagal syncope: Insights from a multicentre observational study
21 nov. 2025 01:00 - SFR Icat
CONCLUSIONS: CPAP therapy significantly reduces RVS recurrence in patients with OSA, suggesting that it is a modifiable risk factor for RVS. These findings highlight the importance of OSA screening in patients with unexplained syncope. Randomized controlled trials are required to mitigate potential results bias caused by the observational study design.
Kidney transplantation from donors with cancer or history of cancer: Transplantation and cancerology committee of Association Française d'Urologie guidelines (CTAFU/CCAFU)
21 nov. 2025 01:00 - SFR Icat
CONCLUSION: The use of donors with a tumor or a history of urological tumor may be considered and should allow the pool of potential donors to be expanded. Guidelines have been established not to lose healthy organs, without compromising the safety of the recipient.
Hearing loss in French survivors of childhood and adolescent leukemia: impact on quality of life and schooling difficulties
19 nov. 2025 01:00 - SFR Icat
CONCLUSION: Hearing loss should have consequences in the quality of life and the schooling course. It is essential to carry out systematic screening during and after the implicated treatments.
Association between return-to-work trajectories and depressive symptoms in long-term breast cancer survivors: results from the French CONSTANCES cohort
19 nov. 2025 01:00 - SFR Icat
CONCLUSION: Returning to work or pursuing new professional opportunities after BC may reduce the risk of long-term DS.