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Publications
Role of molecular alterations in transplantation decisions for patients with primary myelofibrosis
19 nov. 2024 01:00 - SFR Icat
The aim of our study was to analyze the potential survival benefit associated with HSCT according to clinico-biological scores which incorporate molecular data (MIPSS70 and MIPSS70+V2) to facilitate decision-making in this context. One transplant (n=241) and one non-transplant cohorts (n=239) were used to test the hypothesis that PMF patients with higher risk molecular score benefit from HSCT. A weighted propensity score was applied to balance confounding factors with the transplanted cohort as...
Blood Pressure Targets for Adults with Vasodilatory Shock - An Individual Patient Data Meta-Analysis
18 nov. 2024 01:00 - SFR Icat
CONCLUSIONS: Targeting a lower mean arterial blood pressure for vasopressor therapy in critically ill patients with vasodilatory shock possibly reduced 90-day all-cause mortality. However, the certainty of evidence is low, and this analysis does not exclude the possibility that lower targets may cause harm overall.
Assessment of an oocyte retrieval simulation training program for residents: From training to clinical practice
18 nov. 2024 01:00 - SFR Icat
CONCLUSION: The ORSTP does not improve the residents' clinical performance, but it could decrease their stress and improve their confidence in clinical practice.
Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1)
13 nov. 2024 01:00 - SFR Icat
Environmental factors, including mechanical stress and surrounding lipids, can influence the response of GPCRs, such as the mechanosensitive angiotensin II type 1 receptor (AT1). To investigate the impact of these factors on AT1 activation, we developed a steered molecular dynamics simulations protocol based on quaternion formalism. In this protocol, a pulling force was applied to the N-terminus of transmembrane helix 6 (TM6) to induce the TM6 opening characteristic of activation. Subsequently,...
CRCI<sup>2</sup>NA inaugural symposium: A meeting on tumor and immune ecosystems
9 nov. 2024 01:00 - SFR Icat
The CRCI²NA inaugural symposium, a meeting on tumor and immune ecosystems, took place in the vibrant and picturesque city of Nantes. The meeting gathered world-renowned experts in cancer biology and immunology. It showcased the most advanced science on mechanisms driving cellular heterogeneity, plasticity, and signaling in normal and cancer cellular ecosystems, which contribute to cancer development, progression, and therapeutic resistance. Recent developments in cancer immunotherapy and...
Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours
8 nov. 2024 01:00 - SFR Icat
CONCLUSION: While delineating tumour types among the FGFR2-fused glioneuronal tumour spectrum, by histopathology or DNA-methylation profiling, remains challenging, neuroimaging data revealed two distinct patterns that could correlate to PLNTY and ganglioglioma. However, more series including extensive histo-radio-molecular data are needed to confirm this hypothesis.
Model-based characterization of total serum bilirubin dynamics in preterm infants
7 nov. 2024 01:00 - SFR Icat
CONCLUSIONS: Our model effectively characterized TSB dynamics for 72 patients, providing valuable insights from model parameters and fitting errors. To our knowledge, this is the first long-term mathematical description of natural TSB decay in preterm infants. Furthermore, the model was able to estimate the occurrence of clinical events such as necrotizing enterocolitis, as reflected by the relatively high RMSE. Future implications include the development of model-based clinical decision support...
CPAP recall and cancer risk: should we be concerned?
7 nov. 2024 01:00 - SFR Icat
No abstract
Pulmonary hypertension in patients carrying FLNA loss-of-function variants
7 nov. 2024 01:00 - SFR Icat
CONCLUSIONS: Precapillary PH, likely due to multiple mechanisms, may complicate the course of patients with LOF FLNA variants and may be the presenting symptom leading to diagnosis. The combination of PH with parenchymal involvement and extrapulmonary symptoms (epilepsy, congenital heart diseases, valvular and aortic involvement, thrombocytopenia) should prompt genetic screening for FLNA.
Systematic vitamin K antagonist reversal with prothrombin complex concentrate in patients with mild traumatic brain injury: randomized controlled trial
7 nov. 2024 01:00 - SFR Icat
CONCLUSION: In patients with recent mild-TBI receiving a VKA, systematic prompt reversal with 4f-PCC did not statistically significantly reduce ICH rate at 24 h. However, the study was prematurely stopped and does not exclude a clinically relevant benefit of the strategy tested.
Characteristics of Engagement and Persistence of Teachers in an Innovative Master Programme Focused on the "One Health" Concept: A Qualitative Study
6 nov. 2024 01:00 - SFR Icat
We aimed to describe the characteristics of teachers' engagement and persistence in an innovative multidisciplinary health programme. Participants in this descriptive and comprehensive study consisted of teachers in higher education (veterinary medicine, human medicine, pharmacy, engineers in husbandry) who were involved in the conception and the implementation of an international Master programme called MAN-IMAL. This programme was characterized by interculturality, multidisciplinarity, using...
Bioactive dextran-based scaffolds from emulsion templates co-stabilized by poly(lactic-co-glycolic acid) nanocarriers
1 nov. 2024 01:00 - SFR Icat
Porous polymer scaffolds are widely investigated as temporary implants in regenerative medicine to repair damaged tissues. While biocompatibility, degradability, mechanical properties comparable to the native tissues and controlled porosity are prerequisite for these scaffolds, their loading with pharmaceutical or biological active ingredients such as growth factors, in particular proteins, opens up new perspective for tissue engineering applications. This implies the development of scaffold...
Reduced microvascular flow-mediated dilation in Syrian hamsters lacking d-sarcoglycan is caused by increased oxidative stress
1 nov. 2024 01:00 - SFR Icat
d-sarcoglycan mutation reduces mechanotransduction and induces dilated cardiomyopathy with aging. We hypothesized that in young hamsters with d-sarcoglycan mutation, which do not show cardiomyopathy, flow mechanotransduction might be affected in resistance arteries as the control of local blood flow. Flow-mediated-dilation (FMD) was measured in isolated mesenteric resistance arteries, using 3-months old hamsters carrying a mutation in the d-sarcoglycan gene (CH-147) and their control...
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models
31 oct. 2024 01:00 - SFR Icat
The identification of a point mutation (p.Ser59Leu) in the CHCHD10 gene was the first genetic evidence that mitochondrial dysfunction can trigger motor neuron disease. Since then, we have shown that this mutation leads to the disorganization of the MItochondrial contact site and Cristae Organizing System (MICOS) complex that maintains the mitochondrial cristae structure. Here, we generated yeast mutant strains mimicking MICOS instability and used them to test the ability of more than 1600...
The Emergency Advisory and Research international board on Thrombosis and Hemostasis (EARTH)
31 oct. 2024 01:00 - SFR Icat
No abstract
