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Peritoneal recurrence following nephrectomy for localized renal cancer: A multicenter European real-world analysis of incidence, pattern and treatment (PEMET study-UroCCR 124)
5 sept. 2025 02:00 - SFR Icat
CONCLUSIONS: PREC incidence was below 1%. Our results suggest 2 distinct mechanisms. One involves local spread, potentially favored by MIS and PN, while the other corresponds to a metastatic dissemination driven by tumor aggressiveness. iPREC appears to have better prognosis as compared to mPREC and be effectively treated with surgery.
Diagnostic Impasse and Wandering in Patients With Rare Neuromuscular Diseases: Insights Into Patient Characteristics From the French National Network for Rare Neuromuscular Diseases (FILNEMUS) and the French National Rare Disease Database (BNDMR)
4 sept. 2025 02:00 - SFR Icat
CONCLUSIONS: The FILNEMUS national network of expert centers has enabled equality of care for RNMD patients across France, but further measures are needed to promote more rapid referral to these centers, reduce times to first consultation, and maintain patient engagement in the diagnostic process, particularly for later-onset RNMDs.
Prevalence and predictors of uncommon features in FSHD1 patients: insights from the French FSHD registry
2 sept. 2025 02:00 - SFR Icat
CONCLUSIONS: This study documents uncommon FSHD features, revealing their association with the 8-10 RU range and later age of onset. These findings further support a complex interplay among genetic and epigenetic modifiers and ageing in shaping the clinical phenotype of FSHD, especially in patients carrying borderline D4Z4 arrays. Differential phenotypes, particularly in relation to RU range and age of onset, points to the importance of harmonized, comprehensive clinical and genetic assessments....
Erratum à « En aparté : entretien avec le Pr Mathilde Duchesne » [Ann. Pathol. 45 (4) (2025) 285–6]
2 sept. 2025 02:00 - SFR Icat
No abstract
ESA VIVALDI Dry Immersion Microgravity Simulations Induce Increases in Immune Biomarkers Associated With Physical and Psychological Stress, and Sex-Specific Factors
2 sept. 2025 02:00 - SFR Icat
With future manned space projects involving missions of unprecedented duration, multisystem deconditioning induced by spaceflight could seriously affect the well-being and health of astronauts. Safe and easily determined in-flight biomarkers are therefore needed to monitor health status. In this study, we simulated space deconditioning with a 5-day dry immersion (DI) of 18 healthy women and 19 healthy men and evaluated the effects of this protocol on three biomarkers: the...
Results of a French screening campaign comparing clinical and molecular characteristics of interval colorectal cancers to cancers detected using a guaiac test
1 sept. 2025 02:00 - SFR Icat
Few studies have analyzed the biological characteristics of interval colorectal cancers (CRC) during a screening campaign. We included 98 patients of whom 46 had a screened cancer (SCG) and 52 an interval cancer (ICG). Microsatellite instability and gene mutation profiling were performed in 86 and 55 patients, respectively. ICG were diagnosed with more advanced diseases. A time interval between last negative test and CRC diagnosis (TIg2D) ≥ 18 months, in the ICG, was associated with an increased...
French expert consensus statement on diagnosis and MANAGEMENT of PRIMARY HYPERPARATHYROIDISM
1 sept. 2025 02:00 - SFR Icat
In 2024, the French Society of Endocrinology, the French speaking association of endocrine surgery, and the French society of nuclear medicine have elaborated a joint consensus statement on primary hyperparathyroidism, which was presented at the last congress of the French Society of Endocrinology, in October 2024, and subsequently published as 15 individual chapters in the Annals of Endocrinology. This consensus statement is a fruit of a joint effort by over 80 French-speaking experts in the...
Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic-Pharmacodynamic Analysis
1 sept. 2025 02:00 - SFR Icat
CONCLUSION: The relationship between paracetamol and the time-course of ductus arteriosus diameter has been described in extremely preterm neonates. Intravenous paracetamol treatment with a loading dose of 25 mg/kg within 12 h after birth followed by 10 mg/kg every 6 h appears to be effective to accelerate time to ductus closure with limited benefit of a further dose increase.
Clinical Presentation and Outcomes After Surgery for Mitral Regurgitation: Real-World Insights From the MITRACURE International Registry
31 août 2025 02:00 - SFR Icat
CONCLUSIONS: MITRACURE provides a contemporary, multicenter, "real-world" picture of the clinical presentation, management, and in-hospital outcomes of MVS for MR in two Western countries. Patients were often referred late in the disease process, with few patients undergoing early intervention. The higher mortality and lower repair rates reported may be more reflective of an unselected MR patient population but have room for improvement. Our results underline the need to develop strategies to...
Association between obstructive sleep apnoea and liver fibrosis in patients with suspected nonalcoholic fatty liver disease
30 août 2025 02:00 - SFR Icat
CONCLUSIONS: Utilizing the gold-standard tools for OSA and NAFLD diagnosis in a multicentric cohort of biopsy-proven NAFLD patients, an independent association between OSA and liver fibrosis was confirmed.
Response to "Acquired pseudoxanthoma elasticum progressing after chronic liver transplant rejection" by Tardieu et al. Ann Dermatol Venereol 2025;152:103416: Could anti-ABCC6 antibodies cause pseudoxanthoma elasticum after liver transplantation?
29 août 2025 02:00 - SFR Icat
No abstract
Corrigendum to 'Pain intensity after robotic-assisted urological surgery: The PAIROU study an international prospective cohort study' [ACCPM (2025) 101546]
26 août 2025 02:00 - SFR Icat
No abstract
Cost-Utility Analysis Alongside the GORTEC 2014-01 TPExtreme trial: TPEx versus EXTREME as first-line treatment in patients with recurrent or metastatic head and neck squamous cell carcinoma
23 août 2025 02:00 - SFR Icat
CONCLUSION: The TPEx regimen is likely to be cost-effective compared to EXTREME in the French setting.
Prospective Multicenter Evaluation of [<sup>11</sup>C]Methionine PET/MRI Sensitivity Compared with MRI for Localizing Small Pituitary Neuroendocrine Tumor or Pituitary Adenoma in Cushing Disease
21 août 2025 02:00 - SFR Icat
Functional small pituitary neuroendocrine tumors (PitNETs) of the corticotroph type lead to Cushing disease (CD), a condition associated with significant morbidity and increased mortality. Pituitary MRI is the primary imaging modality used to localize the tumor, but it is inconclusive in up to 30% of cases. Accumulating retrospective evidence suggests that [^(11)C]methionine ([^(11)C]MET) PET could address this diagnostic gap. This prospective study evaluates the sensitivity of [^(11)C]MET...
Standardized Infliximab Regimen to Treat Severe Central Nervous System Tuberculosis: A Case Series of 18 Patients
18 août 2025 02:00 - SFR Icat
CONCLUSIONS: Infliximab may represent a promising adjunctive treatment for CNS TB unresponsive to SOC, including paradoxical reaction. Prospective studies are needed to confirm these findings.