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Publications

Scleromyxedema-Associated Myopathy and Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS) as manifestations of Monoclonal Gammopathy of Clinical Significance (MGCS): a disease spectrum between autophagy dysfunction and inflammation
29 sept. 2026 02:00 - SFR Icat
Scleromyxedema-Associated Myopathy (SAM) and Vacuolar Myopathy with Monoclonal Gammopathy and Stiffness (VAMMGAS) are rare clinical entities associated with Monoclonal Gammopathy of Clinical Significance (MGCS). We compared the clinical, neurophysiological, histopathological, and ultrastructural features of three patients (two with SAM and one with VAMMGAS), together with a review of the available literature, to further characterize the similarities and differences between these two conditions....
Biopsy and identification of risk factors for discordance in renal tumor: results from the BIRD study (UroCCR n°230)
28 sept. 2026 02:00 - SFR Icat
CONCLUSIONS: RMB provided a high diagnostic yield but was associated with an overall 18% discordance rate. Cystic tumors were the only independent factor associated with an increased risk of discordance, while tumor complexity and size influenced discordance subtypes. Regarding ISUP grade, RMB showed imperfect reliability, failing to reflect true tumor aggressiveness in nearly half of discordant cases.
The Friday Effect: Why Do XDR Alerts Seem to Arrive Before the Weekend?
25 sept. 2026 02:00 - SFR Icat
No abstract
Cytokine follow-up complements CAR-HEMATOTOX score to predict severe cytopenia in B-cell malignancies treated with CAR T cells
25 sept. 2026 02:00 - SFR Icat
No abstract
CDKN2A/B status can be assessed by p16/MTAP immunohistochemistry as a practical surrogate in pleomorphic xanthoastrocytoma and high-grade astrocytoma with piloid features
23 sept. 2026 02:00 - SFR Icat
The presence of a CDKN2A homozygous deletion (HD) plays an important role in the diagnostic approach of neuropathologists to several central nervous system (CNS) tumors. CDKN2A is located on chromosome 9p21, next to CDKN2B and MTAP, and encodes for the protein p16. CDKN2A/B HD constitutes a frequent alteration in some circumscribed gliomas such as high-grade astrocytomas with piloid features (HGAP) and pleomorphic xanthoastrocytomas (PXA). The diagnosis of these tumor types remains complex and...
Identification of a human mitochondrial isoform of TRPV1: a thermostat regulating mitochondrial maximal temperature?
21 sept. 2026 02:00 - SFR Icat
Mitochondria are well known to produce ATP for cell energy requirements and thermogenesis simultaneously by the respiratory chain, with a potential optimum temperature of 50 °C, while deleterious overheating should be prevented by a yet unknown system. Here, we report the identification of a human Transient Receptor Potential Vanilloid 1 (mitoTRPV1) alternative isoform located in the mitochondrial inner membrane, which acts as a thermostat regulating mitochondrial maximal temperature. The...
Colonic LRRK2 expression is increased in Crohn's disease but not in Parkinson's disease and idiopathic RBD
19 sept. 2026 02:00 - SFR Icat
No abstract
Impact of resection bed management on postoperative outcomes after Robot-Assisted Partial Nephrectomy : a retrospective French Nationwide Study (UroCCR 215)
18 sept. 2026 02:00 - SFR Icat
CONCLUSION: In this large, multicenter cohort, various hemostatic techniques during RAPN showed overall comparable safety profiles, except for a higher transfusion rate associated with sutureless without HA approaches, and a protective effect on vascular complications of DLS with HA.
Three-dimensional cell culture models in oncology: From tumour spheroids to integrated microphysiological systems
17 sept. 2026 02:00 - SFR Icat
Traditional two-dimensional (2D) cell cultures fail to capture the structural, mechanical, and biochemical complexity of living tissues, prompting a major paradigm shift toward three-dimensional (3D) cell culture models. 3D systems faithfully replicate in vivo physiological architectures, dynamic cell-to-cell contacts, and extracellular matrix (ECM) interactions, bridging a critical gap in preclinical studies by predicting human therapeutic responses more accurately. This review explores the...
What a negative trial does not tell us: Bayesian reanalysis of the enteral citrulline supplementation versus placebo on SOFA score on day 7 in mechanically ventilated critically ill patients randomized clinical trial
17 sept. 2026 02:00 - SFR Icat
CONCLUSION: This Bayesian reanalysis demonstrates that the IMMUNOCITRE trial was insufficiently powered to characterize the effect of l-citrulline on organ dysfunction. In this unselected cohort with low-to-moderate initial severity, the probability of achieving a large, clinically meaningful benefit remains limited. These findings do not support immediate clinical implementation. Future multicenter randomized controlled trial is highly warranted but should specifically target patients with...
Association of antifungal treatment duration with 90-day mortality in critically ill adults with candidemia: a multicenter target trial emulation in France
17 sept. 2026 02:00 - SFR Icat
BACKGROUND: The optimal duration of antifungal therapy for candidemia in intensive care unit (ICU) patients remains uncertain. We aimed to evaluate whether shorter antifungal therapy was not associated with increased mortality using a target trial emulation framework.
B-Cell Remodeling and Regulatory Phenotypes During Acute COVID-19 Are Unaffected by Polyclonal Anti-SARS-CoV-2 Antibody XAV-19
16 sept. 2026 02:00 - SFR Icat
Regulatory B cells (Bregs) are emerging as pivotal modulators of immune balance, yet their dynamics during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their response to passive antibody therapy remain largely unexplored. In the immunological sub-study of the randomized, placebo-controlled POLYCOR trial evaluating XAV-19, a glyco-humanized polyclonal anti-SARS-CoV-2 antibody, we performed longitudinal immune profiling of hospitalized COVID-19 patients using spectral...
Peripheral TDP-43 pathology in amyotrophic lateral sclerosis: toward a systemic proteinopathy
15 sept. 2026 02:00 - SFR Icat
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive degeneration of upper and lower motor neurons. Cytoplasmic accumulation of phosphorylated TAR DNA-binding protein 43 (pTDP-43) is the pathological hallmark of most ALS cases. While ALS has traditionally been viewed as a disease confined to the brain, spinal cord and motor nerves, recent studies have reported pTDP-43 pathology in multiple other tissues (skeletal and cardiac muscle, skin, minor...
The blood cell-derived bioactive lipid sphingosine 1-phosphate maintains blood pressure and cardiac function
14 sept. 2026 02:00 - SFR Icat
No abstract
mtDNA alterations in muscle progenitors determine myoblast differentiation and disrupt skeletal muscle architecture
12 sept. 2026 02:00 - SFR Icat
Mitochondrial DNA (mtDNA) damage has been linked to age-related tissue decline, yet its impact on muscle stem cells (MuSCs) integrity remains unclear. Here, we used a dominant-negative variant of the mitochondrial helicase Twinkle (p.K320E) to induce mtDNA instability in C2C12 and MuSCs, and examined myogenic differentiation. In C2C12, mtDNA alterations impaired respiratory complex assembly, increased reactive oxygen species, and disrupted differentiation. Proteomic analyses of differentiated...