Index
>Publications

Publications

Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy
9 juil. 2026 02:00 - SFR Icat
Methionine dependence represents a well-known metabolic vulnerability in cancer. Despite promising preclinical results, methionine restriction is impaired by the presence of methionine-independent cancer cells. After confirming both inter- and intra-tumoral heterogeneity in methionine dependence, we demonstrate that "methionine-independent" cells are rather "methionine self-sufficient," relying on the vitamin B12 (B12)-dependent methionine synthase (MTR) to sustain growth without exogenous...
Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Treated with Hepatic Arterial Infusion of Oxaliplatin: A Case Report with Longitudinal Molecular Profiling
9 juil. 2026 02:00 - SFR Icat
CONCLUSION: This case illustrates a rare metastatic PACC achieving prolonged survival through local control at the hepatic level, thanks to 42 cycles of HAI of oxaliplatin. It suggests that HAI may represent a feasible and effective regional strategy for selected patients with predominant liver involvement. The longitudinal molecular profiling shows the importance of re-biopsy to detect emerging actionable alterations and guide inclusion in targeted clinical trials.
Pharmacogenetics in sexualized drug use: considerations for a precision addiction medicine approach
8 juil. 2026 02:00 - SFR Icat
No abstract
Exercise impairment in patients with pectus excavatum? A scoping review of evidence and role of arterial content change during effort
7 juil. 2026 02:00 - SFR Icat
This scoping review describes cardiopulmonary fitness in non-operated patients with pectus excavatum and maps the reporting of hemoglobin and arterial oxygen content during exercise. Four databases (PubMed, ScienceDirect, CINAHL, and SPORTDiscus) were searched from inception to February 15th, 2025. Cross-sectional studies, cohort studies, and randomized controlled trials reporting exercise capacity or exercise testing outcomes were included. Among 612 identified records, 31 studies involving...
Proteomic Profiling of Endothelial Cells Under Laminar Shear Stress Confirms the Importance of KLF4 in the Regulation of Membrane Protein Expression Compared to Oscillatory Flow
6 juil. 2026 02:00 - SFR Icat
Endothelial cells (ECs) are key regulators in vascular homeostasis, and their physiological state depends on hemodynamic forces produced by the blood flow. Laminar shear stress (LSS) maintains endothelial integrity, whereas oscillatory shear stress (OSS) leads to endothelial dysfunction and subsequently to cardiovascular disease. Here, we delineated the proteomic signatures of human umbilical vein endothelial cells (HUVECs) exposed to a protective flow (LSS) or a disturbed flow (OSS) in...
Sedation Early After Return of Spontaneous Circulation and During Pre-Hospital Transport After Out-Of-Hospital Cardiac Arrest: Retrospective Analysis of the AfterROSC1 & 2 Database
4 juil. 2026 02:00 - SFR Icat
CONCLUSION: The decision of sedation started after ROSC and before ICU admission was associated with a good functional recovery on day 90. However, the design of this study does not allow us to establish a causal link between pre-hospital sedation and improved neurological recovery. In particular, it is not possible to formally rule out residual indication bias. A randomized trial assessing the effect of early sedation on treatment strategies and patient outcomes is needed.
Effectiveness of a pharmacist-led protocol to manage cystitis in women, in France: the PharmaCyst' open-label, multicenter, randomized, controlled, cluster study
1 juil. 2026 02:00 - SFR Icat
CONCLUSION: Pharmacists' management of cystitis in women leads to a greater reduction in symptoms at day 3.
Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes
27 juin 2026 02:00 - SFR Icat
CONCLUSION: Unsupervised clustering identified three clinically different candidemia phenotypes with different outcomes. Cirrhosis, higher age and illness severity were associated with mortality, whereas a catheter-related source of infection was protective.
Surgery after neoadjuvant chemotherapy for synchronous and exclusive peritoneal metastasis from colorectal cancer: a descriptive retrospective cohort study
25 juin 2026 02:00 - SFR Icat
CONCLUSIONS: In CRC patients with isolated PC, complete CRS is a key survival factor. HIPEC seems to lead to an improvement in overall survival among our patients, and its benefits remain a subject of debate. Further trials are needed to define optimal regimens and personalize strategies.
Partial Nephrectomy Versus Thermal Ablation for Cystic Renal Tumors: A Registry-Based, Propensity Score Matched Analysis (UroCCR n°177)
23 juin 2026 02:00 - SFR Icat
CONCLUSIONS: Ablative treatment of cystic renal tumors appears feasible and safe. Thermal ablation confirms its lower perioperative impact on hospital stay and overall complications. As for local recurrence, progression and cancer specific death, no statistically significant difference was observed between PN and TA.
The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina
23 juin 2026 02:00 - SFR Icat
BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive analysis of BRI23 interactome in the human retina. Using a peptide-bead coupling system, we identified 2302 proteins, primarily involved in mitochondrial processes, synaptic transmission and...
Clinical and microbiological features in community- and hospital-acquired extended spectrum beta lactamase producing Escherichia coli from urinary tract
23 juin 2026 02:00 - SFR Icat
No abstract
Relative frequencies of muscle specific kinase antibody myasthenia in 46 centres worldwide
23 juin 2026 02:00 - SFR Icat
Serum antibodies to muscle specific kinase (MuSK) are present in a proportion of patients with acetylcholine receptor antibody seronegative myasthenia gravis (SNMG), but their reported frequencies in different populations vary. From 2002, serum samples were sent to Oxford for MuSK antibody testing from 35 centres in 6 continents. MuSK antibodies were identified in 143/465 (30.8%) previously untested SNMG sera. They were not identified in 147 adult acetylcholine receptor antibody positive...
MiT fusions, TSC1-TSC2 divergence, and stem-like programs reveal distinct origins and vulnerabilities in PEComa
22 juin 2026 02:00 - SFR Icat
Perivascular epithelioid cell neoplasms (PEComas) are ultra-rare mesenchymal tumors lacking a molecular classification to guide therapy. Here we perform comprehensive multi-omic profiling of an unselected PEComa cohort. We identify frequent MITF rearrangements involving actin gene partners (ACTA2, ACTG1 and ACTB). Anatomical stratification reveals cyclin-dependent kinase module mutations in gynecologic tumors, whereas soft tissue, gastrointestinal, and pelvic tumors lacked mTOR pathway...
Endometrial metabolomic profiling reveals disruption of fatty-acid metabolism in unexplained recurrent pregnancy loss
22 juin 2026 02:00 - SFR Icat
CONCLUSION: A disruption of fatty acid metabolism was observed in the endometrium during the implantation window in U-RPL, paving the way for the identification of novel biomarkers of endometrial receptivity.