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Publications

Effectiveness of a pharmacist-led protocol to manage cystitis in women, in France: the PharmaCyst' open-label, multicenter, randomized, controlled, cluster study
1 juil. 2026 02:00 - SFR Icat
CONCLUSION: Pharmacists' management of cystitis in women leads to a greater reduction in symptoms at day 3.
Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes
27 juin 2026 02:00 - SFR Icat
CONCLUSION: Unsupervised clustering identified three clinically different candidemia phenotypes with different outcomes. Cirrhosis, higher age and illness severity were associated with mortality, whereas a catheter-related source of infection was protective.
Surgery after neoadjuvant chemotherapy for synchronous and exclusive peritoneal metastasis from colorectal cancer: a descriptive retrospective cohort study
25 juin 2026 02:00 - SFR Icat
CONCLUSIONS: In CRC patients with isolated PC, complete CRS is a key survival factor. HIPEC seems to lead to an improvement in overall survival among our patients, and its benefits remain a subject of debate. Further trials are needed to define optimal regimens and personalize strategies.
Partial Nephrectomy Versus Thermal Ablation for Cystic Renal Tumors: A Registry-Based, Propensity Score Matched Analysis (UroCCR n°177)
23 juin 2026 02:00 - SFR Icat
CONCLUSIONS: Ablative treatment of cystic renal tumors appears feasible and safe. Thermal ablation confirms its lower perioperative impact on hospital stay and overall complications. As for local recurrence, progression and cancer specific death, no statistically significant difference was observed between PN and TA.
The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina
23 juin 2026 02:00 - SFR Icat
BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia. Its role in the retina remains poorly understood. This study provides a comprehensive analysis of BRI23 interactome in the human retina. Using a peptide-bead coupling system, we identified 2302 proteins, primarily involved in mitochondrial processes, synaptic transmission and...
Clinical and microbiological features in community- and hospital-acquired extended spectrum beta lactamase producing Escherichia coli from urinary tract
23 juin 2026 02:00 - SFR Icat
No abstract
Relative frequencies of muscle specific kinase antibody myasthenia in 46 centres worldwide
23 juin 2026 02:00 - SFR Icat
Serum antibodies to muscle specific kinase (MuSK) are present in a proportion of patients with acetylcholine receptor antibody seronegative myasthenia gravis (SNMG), but their reported frequencies in different populations vary. From 2002, serum samples were sent to Oxford for MuSK antibody testing from 35 centres in 6 continents. MuSK antibodies were identified in 143/465 (30.8%) previously untested SNMG sera. They were not identified in 147 adult acetylcholine receptor antibody positive...
MiT fusions, TSC1-TSC2 divergence, and stem-like programs reveal distinct origins and vulnerabilities in PEComa
22 juin 2026 02:00 - SFR Icat
Perivascular epithelioid cell neoplasms (PEComas) are ultra-rare mesenchymal tumors lacking a molecular classification to guide therapy. Here we perform comprehensive multi-omic profiling of an unselected PEComa cohort. We identify frequent MITF rearrangements involving actin gene partners (ACTA2, ACTG1 and ACTB). Anatomical stratification reveals cyclin-dependent kinase module mutations in gynecologic tumors, whereas soft tissue, gastrointestinal, and pelvic tumors lacked mTOR pathway...
Endometrial metabolomic profiling reveals disruption of fatty-acid metabolism in unexplained recurrent pregnancy loss
22 juin 2026 02:00 - SFR Icat
CONCLUSION: A disruption of fatty acid metabolism was observed in the endometrium during the implantation window in U-RPL, paving the way for the identification of novel biomarkers of endometrial receptivity.
Soluble CD95L triggers Caspase-10-driven reactive oxygen species production in neutrophils and aggravates anti-neutrophil cytoplasmic antibody-vasculitis
19 juin 2026 02:00 - SFR Icat
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune disease that lacks effective targeted therapies. T cell and neutrophil activation are associated with tissue lesions in ANCA-associated vasculitis responsible for the necrotizing vasculitis of small blood vessels. Although the aberrant release of reactive oxygen species (ROS) by neutrophils contribute to the disruption of the endothelial barrier, the underlying molecular mechanisms of this oxidative...
Reply: <em>FLNA</em> loss-of-function variants in pulmonary hypertension: implications for genetic testing in congenital heart disease
18 juin 2026 02:00 - SFR Icat
No abstract
CGM-based metrics and mortality in older adults living with type 2 diabetes on insulin therapy: a secondary analysis of the HYPOAGE study
16 juin 2026 02:00 - SFR Icat
CONCLUSION: Among insulin-treated older adults living with type 2 diabetes, glycemic variability was independently associated with all-cause mortality, highlighting its potential relevance for clinical management in geriatric diabetes care.
Unexpected Voriconazole Overexposure in a CYP2C19 Rapid Metabolizer Due to Inflammation-Induced Phenoconversion: A Short Communication
16 juin 2026 02:00 - SFR Icat
CONCLUSIONS: This case highlights the importance of an integrated approach to voriconazole therapy that combines pharmacogenetics, inflammatory status, and therapeutic drug monitoring. Recognizing inflammation-induced phenoconversion as a dynamic determinant of drug metabolism may improve the safety and efficacy of antifungal treatment.
A simplified geometric CMR method for reproducible quantification of left ventricular thrombus volume : Left Ventricular thrombus: a standardized measurement method
15 juin 2026 02:00 - SFR Icat
Left ventricular thrombus (LVT) is a frequent complication after myocardial infarction and is associated with increased risk of systemic embolism and adverse cardiovascular outcomes. However, the relationship between thrombus characteristics and its clinical evolution remains poorly understood, partly due to the lack of standardized and reproducible measurement methods. This study evaluated the feasibility and reproducibility of a simplified geometric CMR approach for standardized LVT volume...
Overall survival of patients with localized soft tissue sarcoma treated with or without adjuvant chemotherapy (DEEPSARC): a real world nationwide retrospective cohort study in France
15 juin 2026 02:00 - SFR Icat
BACKGROUND: Whether adjuvant chemotherapy (AC) improves overall survival (OS) after complete resection in localized soft tissue sarcoma (STS) remains unproven and optional in guidelines. We measured OS in patients with operated non-metastatic STS treated with or without AC in the nationwide exhaustive NETSARC+ registry.