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Publications

Surgery for hypertrophic obstructive cardiomyopathy: the European perspective
30 janv. 2026 01:00 - SFR Icat
Europe has played a foundational role in understanding hypertrophic cardiomyopathy (HCM), yet surgical treatment-particularly septal myectomy-has seen uneven adoption across the continent. Widespread reliance on alcohol septal ablation (ASA) and the more recent introduction of cardiac myosin inhibitors (CMIs) have contributed to a decline in surgical expertise. This perspective reviews the historical evolution of HCM surgery in Europe and the impact of contemporary figures and centers. Drawing...
Risk score for lower-limb amputation and its ability to predict major kidney and cardiovascular events in people with type 1 diabetes
30 janv. 2026 01:00 - SFR Icat
CONCLUSION: This newly developed 10-year LLA risk score achieved excellent ability to identify individuals with type 1 diabetes at high risk for LLA, kidney failure, CVD, and MACE.
Classification of angioedema types using decision tree modeling
28 janv. 2026 01:00 - SFR Icat
INTRODUCTION: All angioedema (AE) presents with transient, localized swelling; however, the underlying causes, prognosis, and treatments vary significantly. Consequently, identifying a specific AE type is challenging.
Impact of obesity and preconceptional bariatric surgery on feto-placental unit in a rat model: a preliminary study
28 janv. 2026 01:00 - SFR Icat
Obesity and overweight in pregnant women increase pregnancy and neonatal morbidity with a risk of metabolic syndrome for children in later life. Maternal preconceptional bariatric surgery reduces maternal and paediatric outcomes but may induce fetal nutritional deficiencies and intrauterine growth restriction through placental reprogramming. The aim of this study was to describe feto-placental unit modifications induced by obesity, and the effect of bariatric surgery performed before gestation,...
Tracing the origin and evolution of specialized biosynthetic pathways in marine organisms
27 janv. 2026 01:00 - SFR Icat
Harmful algal blooms (HABs) pose public health and ecological risks in aquatic environments. HABs drive the bioaccumulation of a specific family of specialized metabolites known as "kainoids." Kainoid derivatives, such as kainic acid (KA) and domoic acid (DA), are among the most toxic marine-derived metabolites produced by a limited number of algal species. While recent studies have provided insights into the molecular basis of KA and DA production in red algae and diatoms, knowledge of the...
Impact of War-Related Bowel Resection on Pain Management: Is There Need for a Tailored Prescribing Approach? A Letter to the Editor
26 janv. 2026 01:00 - SFR Icat
No abstract
Study of Insulin Treatment Modalities in Adults With Cystic Fibrosis-Related Diabetes After Elexacaftor-Tezacaftor-Ivacaftor Therapy
23 janv. 2026 01:00 - SFR Icat
CONCLUSIONS: These findings indicate a reduction in insulin doses, particularly prandial insulin, as well as decreased glucose variability and hypoglycemia following ETI therapy in CFRD patients. Further long-term studies are needed to confirm these results.
Higher Doses of Oral Propranolol for Resistant Infantile Haemangio-mas
23 janv. 2026 01:00 - SFR Icat
Propranolol at 3 mg/kg/day is considered the gold standard for treating infantile haemangiomas. Nevertheless, the management of propranolol-resistant infantile haemangiomas (PRIH) remains challenging. This national multicentre retrospective observational study includes all PRIHs who received propranolol > 3 mg/kg/day. The study aims to investigate the pattern of PRIHs, assess the effects and tolerance of a higher dose, and identify predictive factors for response to this increased dosage....
Major Vascular Complications After Percutaneous Transfemoral Approach for Transcatheter Aortic Valve Implantation in Propensity-Matched Cohort: Impact on Clinical Outcomes and Survival
20 janv. 2026 01:00 - SFR Icat
CONCLUSIONS: Major vascular complications after transfemoral transcatheter valve implantation are associated with worse clinical outcomes and reduced long-term survival despite similar at 30-day mortality. Recognizing high-risk patients, optimizing procedural planning, and considering alternative access routes may help reduce vascular complications.
Health-related quality of life and mental health in autoimmune thrombotic thrombocytopenic purpura patients in the caplacizumab era
19 janv. 2026 01:00 - SFR Icat
CONCLUSION: Based on our results, HRQoL is decreased in patients with iTTP, and depression and anxiety are more prevalent. Caplacizumab treatment might influence long-term mental and psychological outcomes in iTTP by shortening the duration of treatment with plasma exchange.
Real-life use of bone-targeting agents for bone metastases in France between 2009 and 2018: Results of the OPTIMOS study
19 janv. 2026 01:00 - SFR Icat
CONCLUSION: BTAs are underused in bone metastases patients in France. There is an urgent need to optimise bone metastases management in accordance with ESMO 2020 guidelines.
Deciphering the Proteomic Basis of Early Vascular Aging in Hypertensive Patients
19 janv. 2026 01:00 - SFR Icat
No abstract
Well-Being of Student Pharmacists During the Preparation Period of National Pharmacy Internship Competition in France
17 janv. 2026 01:00 - SFR Icat
CONCLUSION: The present study highlighted the psychological distress experienced by student pharmacists preparing for the NPIC. To alleviate this, we propose improving student support, particularly during the summer period.
Sleep apnoea and its consequences: from animal models to precision medicine
17 janv. 2026 01:00 - SFR Icat
A European Respiratory Society research seminar entitled "Sleep Apnoea and Its Consequences: From Animal Models to Precision Medicine" was held in January 2024 in Lisbon, Portugal. It provided an in-depth analysis of the current landscape and future directions in OSA research, integrating recent findings from metabolomics, animal models, clinical predictors of cardiometabolic consequences of OSA, artificial intelligence (AI), and advances in diagnostic algorithms. This article presents a...
CD34-positive circulating cells quantification during follow-up in myeloproliferative neoplasms
16 janv. 2026 01:00 - SFR Icat
Polycythemia vera (PV) and Essential thrombcythemia (ET) are myeloproliferative neoplasms (MPNs) that can progress to secondary myelofibrosis, a complication associated with increased mortality. Circulating CD34-positive cells at diagnosis can be used to distinguish primary myelofibrosis from other MPNs with a threshold of 10/µL. In this study, we evaluate the interest of serial CD34-positive cell quantifications during the follow-up of MPNs. We retrospectively include 180 patients with MPN (90...