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Common Versus External Iliac Arterial Anastomosis in Kidney Transplantation: A Bicentric Retrospective Analysis of Vascular Complications and Graft Outcomes
25 août 2026 02:00 - SFR Icat
BACKGROUND Vascular complications remain a significant concern after kidney transplantation. While external iliac (EI) implantation is standard, common iliac (CI) implantation is occasionally performed in selected cases, particularly in the presence of vascular disease or anatomical constraints. We compared vascular outcomes according to the arterial anastomosis site. MATERIAL AND METHODS We conducted a bicentric retrospective study including kidney transplant recipients between 2015 and 2019....
Monoclonal gammopathy in ANCA-associated glomerulonephritis: prevalence, characteristics and outcomes
18 août 2026 02:00 - SFR Icat
CONCLUSIONS: MG is frequent in patients with ANCA-GN, mainly reflecting age and comorbidity but does not independently influence renal survival, mortality, or progression to hematological malignancy. MG should be considered a coexisting condition rather than a disease modifier in ANCA-GN, although standardized follow-up remains warranted.
Sex Differences in Fatal Poisoning Among Drug Users in France: An Exploratory Analysis of the DRAMES Register
13 août 2026 02:00 - SFR Icat
CONCLUSION: The observed differences in causes of death between women and men, specifically more polydrug related-deaths (especially with pharmaceuticals), highlight the need to address female-specific concerns. Further studies and resources are needed to develop programs dedicated to women with substance use disorders.
Mitochondrial complex I and II inhibiting pesticides activate DELE1-HRI integrated stress signaling but engage distinct cell death programs in human neuronal cells
13 août 2026 02:00 - SFR Icat
Several pesticides exert lethal actions by inhibiting the mitochondrial respiratory chain, yet the determinants of their differential cytotoxicity remain poorly characterized. We provide the first systematic comparison of fenpyroximate (FEN, Complex I inhibitor) and fluxapyroxad (FXX, Complex II inhibitor) in human SH-SY5Y neuronal cells. Both induced concentration-dependent cytotoxicity, with FEN displaying greater potency than FXX (IC₅₀ ≈ 10 vs. 40 μM; confirmed by MTT and trypan blue assays)....
Mask-Type Switching Trajectories and CPAP Use in Long-Term Obstructive Sleep Apnoea: The SwitchAdene Real-World Cohort Study
12 août 2026 02:00 - SFR Icat
CONCLUSIONS: In routine clinical practice, NM, ONM, and INM renewal trajectories were comparable, whereas NCM renewal was associated with unfavourable outcomes. Switching from an NM to an ONM or NPM was associated with poorer CPAP use. NCMs and INMs should not be pooled under the general NPM category.
Big Data Analytics in Urologic Oncology: A Comprehensive Review of Large-scale Database Research and Clinical Applications
11 août 2026 02:00 - SFR Icat
PURPOSE OF REVIEW: Large-scale databases have become an essential resource in urologic oncology, enabling the generation of real-world evidence across broad and diverse patient populations. This narrative review aims to summarize the contribution of population-based cancer registries, hospital-based clinical registries, and administrative healthcare databases to the understanding and management of prostate, bladder, renal, and other genitourinary malignancies.
Association of Positive airway pressure adherence with mortality and cardiovascular events in high vs low risk sleep apnoea patients
6 août 2026 02:00 - SFR Icat
CONCLUSIONS: In sleep-clinic, the association of PAP adherence with reduced MACE risk was stronger in high risk OSA. These findings support the integration of hypoxic and autonomic biomarkers into clinical decision pathways for CV risk reduction in OSA.
Glycemic and Renal Effects of SGLT2 Inhibitors in Monogenic Diabetes: A Real-World National Study
6 août 2026 02:00 - SFR Icat
CONCLUSIONS: In this nationwide cohort of patients with monogenic diabetes-the largest reported to date-SGLT2i therapy was associated with improved glycemic control in individuals with baseline HbA1c ≥ 8%, reduced albuminuria, and showed a favourable safety profile. These findings support SGLT2i as a potential therapeutic option that warrants confirmation in larger controlled studies.
Correction to: Surgery for hypertrophic obstructive cardiomyopathy: the European perspective
6 août 2026 02:00 - SFR Icat
[This corrects the article DOI: 10.1007/s12055-025-02147-8.].
Tofersen Treatment in <em>SOD1</em>-ALS: Real-World Evidence from a Retrospective Multicenter Study in France (FORSLA Study)
4 août 2026 02:00 - SFR Icat
CONCLUSION: Tofersen seems to be associated with slower functional decline and reduced NfL levels. While limitations of retrospective design and ALSFRS-R sensitivity must be acknowledged, these findings provide real-world evidence suggesting a clinical benefit of Tofersen.
Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis
4 août 2026 02:00 - SFR Icat
Among myeloproliferative neoplasms (MPN), prefibrotic myelofibrosis (preMF) was defined as a distinct entity from essential thrombocythemia (ET) and primary overt myelofibrosis (PMF) since the 2016 revision of the World Health Organization (WHO) classification, while precise characterization may be difficult in some instances. In that context, several non-invasive parameters have shown potential to differentiate ET from PMF. The aim of the study was to prospectively evaluate non-invasive...
Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study
3 août 2026 02:00 - SFR Icat
CONCLUSIONS: In early septic shock, a decrease in RRI during a MAP test did not identify patients who would benefit from higher MAP targets to improve renal function. Conversely, the absence of an RRI decrease during the MAP test may help identify patients in whom increasing MAP is associated with increased urine output.
What are the microbial burden and potential pathogens on hospital surfaces before and after cleaning?
30 juil. 2026 02:00 - SFR Icat
Healthcare-associated infections (HCAIs) remain a significant challenge in hospitals, with environmental contamination increasingly recognized as a contributing factor. However, the relationship between surface microbial burden, pathogen presence, and the effectiveness of cleaning interventions remains incompletely understood. This study aimed to describe the microbial contamination of hospital surfaces before and after cleaning, evaluate the impact of an educational intervention targeting...
Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union
29 juil. 2026 02:00 - SFR Icat
CONCLUSION: Some medicinal plants may be cautiously considered in pediatric oncology, but the risks of pharmacokinetic and pharmacodynamic interactions are substantial. This study proposes a shortlist of plants that may be considered and HMPs with potentially good benefit-risk ratios. These findings should not be interpreted as therapeutic recommendations.
Phenotypic Variations in a Large Family with Dominant Optic Atrophy Related to a Novel <em>OPA1</em> Deletion
28 juil. 2026 02:00 - SFR Icat
CONCLUSION: The identification of a large OPA1 deletion in this DOA family illustrates the critical importance of screening for large genomic rearrangements in DOA genes and confirms the high intrafamilial phenotypic variability while correlating BCVA with RNFL and GCL thickness.