Index
>Publications

Publications

The blood cell-derived bioactive lipid sphingosine 1-phosphate maintains blood pressure and cardiac function
14 sept. 2026 02:00 - SFR Icat
No abstract
mtDNA alterations in muscle progenitors determine myoblast differentiation and disrupt skeletal muscle architecture
12 sept. 2026 02:00 - SFR Icat
Mitochondrial DNA (mtDNA) damage has been linked to age-related tissue decline, yet its impact on muscle stem cells (MuSCs) integrity remains unclear. Here, we used a dominant-negative variant of the mitochondrial helicase Twinkle (p.K320E) to induce mtDNA instability in C2C12 and MuSCs, and examined myogenic differentiation. In C2C12, mtDNA alterations impaired respiratory complex assembly, increased reactive oxygen species, and disrupted differentiation. Proteomic analyses of differentiated...
Diagnosis of rare diseases based on facial phenotype: a quantitative assessment using 2D and 3D photography in Stickler syndrome
12 sept. 2026 02:00 - SFR Icat
Stickler syndrome (SS) is a rare genetic disorder caused by mutations in collagen-encoding genes. Patients with SS are at an increased risk of retinal detachment, with ophthalmologic complications often presenting as the first symptom due to significant diagnostic delays. These delays contribute to severe visual impairment, even in early childhood, making diagnostic uncertainty a major clinical challenge. This study assessed the feasibility of early SS detection using facial features. Supervised...
Treatment of growth hormone deficiency with long-acting growth hormones in children, adolescents and adults: Clinical evidence and practical considerations
11 sept. 2026 02:00 - SFR Icat
Growth hormone deficiency (GHD) is a rare endocrine disorder affecting both children and adults that may occur in isolation or as part of multihormonal hypopituitarism. Recombinant human growth hormone (GH) administered as daily injections has long been the standard of care and improves growth, body composition and quality of life. However, daily administration is associated with a substantial treatment burden and adherence is frequently suboptimal, particularly in children and adolescents....
Association Between Continuous Positive Airway Pressure Therapy Adherence and Incident Depression Risk in Patients With Obstructive Sleep Apnoea
10 sept. 2026 02:00 - SFR Icat
Obstructive sleep apnoea (OSA) is associated with major depressive disorder (MDD). However, limited data exist regarding the impact of continuous positive airway pressure (CPAP) on MDD incidence. Data from the Pays de la Loire Cohort were linked to health administrative data to identify incident MDD, defined by antidepressant prescription or hospitalisation for MDD, in patients with no history of psychiatric disorders (depressive, bipolar, psychotic and anxiety disorders) who were prescribed...
Low diagnostic yield of routine preoperative chest CT in patients undergoing partial nephrectomy: A national cohort study using UroCCR data (UroCCR n°216)
10 sept. 2026 02:00 - SFR Icat
CONCLUSIONS: The diagnostic yield of routine preoperative chest CT in patients with clinical T1 RCC is exceedingly low (<0.5%). These data support the omission of routine chest CT in asymptomatic, low-risk cT1 RCC, potentially sparing over 95% of patients from unnecessary imaging, additional tests and surgical delays. A risk-adapted, symptom-guided strategy may optimize patient care while reducing radiation exposure and healthcare costs.
Clinical guidance on evaluation and management of bone fragility in patients with monoclonal gammopathy of undetermined significance (MGUS): an IOF position statement
8 sept. 2026 02:00 - SFR Icat
CONCLUSION: Based on this analysis, we present the International Osteoporosis Foundation (IOF) position statement for bone evaluation and management of these patients. We recommend a risk-adapted treatment strategy. A proposal of bone clinical guidance dedicated to patients with MGUS is presented, suggesting bisphosphonates as the preferred treatment option.
Single-use vs. reusable flexible ureteroscopes: what do our patients prefer?
5 sept. 2026 02:00 - SFR Icat
CONCLUSION: This first study assessing PO on ureteroscope choice found a preference for SUFU, mainly due to the absence of cross-contamination risk despite EC. These findings support patient involvement in ureteroscope selection.
Cardiac MRI identifies interatrial septum late enhancement as a hallmark of amyloidosis
4 sept. 2026 02:00 - SFR Icat
CONCLUSION: Intense anterior IAS LGE - with a specificity of 98 % - represents the most diagnostically relevant CMR feature for CA in this cohort. Its systematic assessment during routine CMR may improve diagnostic discrimination between CA and cardiomyopathy phenocopies.
Allele burden expansion in JAK2 V617F and CALR-mutated myeloproliferative neoplasms predicts disease progression and is associated with anagrelide treatment
1 sept. 2026 02:00 - SFR Icat
No abstract
Pregnancy outcomes in women conceiving after hematopoietic stem cell transplantation versus conventional chemotherapy for childhood or adolescent acute leukemia
31 août 2026 02:00 - SFR Icat
Myeloablative conditioning before hematopoietic stem cell transplantation (HSCT) during childhood or adolescence reduces adult uterine volume, but its impact on future pregnancies remains uncertain. This multicenter study, nested within the LEA cohort, compared 86 pregnancies after HSCT (55 following total-body irradiation [TBI], 31 after high-dose alkylating agents) with 180 pregnancies after conventional chemotherapy in matched leukemia survivors (total: 266 pregnancies, 117 women)....
Expanding outpatient eligibility using a narrow definition of cancer in the Pulmonary Embolism Severity Index
27 août 2026 02:00 - SFR Icat
CONCLUSION: An active-only cancer definition (vs any cancer) in PESI and sPESI classified a larger proportion of PE patients as low risk. No differences in 30-day outcomes were observed in this very low-risk cohort. Studies in higher-risk cohorts are needed.
Common Versus External Iliac Arterial Anastomosis in Kidney Transplantation: A Bicentric Retrospective Analysis of Vascular Complications and Graft Outcomes
25 août 2026 02:00 - SFR Icat
BACKGROUND Vascular complications remain a significant concern after kidney transplantation. While external iliac (EI) implantation is standard, common iliac (CI) implantation is occasionally performed in selected cases, particularly in the presence of vascular disease or anatomical constraints. We compared vascular outcomes according to the arterial anastomosis site. MATERIAL AND METHODS We conducted a bicentric retrospective study including kidney transplant recipients between 2015 and 2019....
Monoclonal gammopathy in ANCA-associated glomerulonephritis: prevalence, characteristics and outcomes
18 août 2026 02:00 - SFR Icat
CONCLUSIONS: MG is frequent in patients with ANCA-GN, mainly reflecting age and comorbidity but does not independently influence renal survival, mortality, or progression to hematological malignancy. MG should be considered a coexisting condition rather than a disease modifier in ANCA-GN, although standardized follow-up remains warranted.
Sex Differences in Fatal Poisoning Among Drug Users in France: An Exploratory Analysis of the DRAMES Register
13 août 2026 02:00 - SFR Icat
CONCLUSION: The observed differences in causes of death between women and men, specifically more polydrug related-deaths (especially with pharmaceuticals), highlight the need to address female-specific concerns. Further studies and resources are needed to develop programs dedicated to women with substance use disorders.