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Publications

Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity
3 avr. 2026 02:00 - SFR Icat
Adiponectin (Adpn) is a potent insulin-sensitizing adipokine with therapeutic promise for type 2 diabetes (T2D) and metabolic dysfunction-associated steatohepatitis (MASH). Its clinical use is limited by challenges in producing stable, bioactive high-molecular weight forms. Adipocyte-derived extracellular vesicles (EVs) naturally carry oligomeric Adpn on their surface, enhancing hormone stability and activity. Here, we engineered EVs displaying membrane-anchored Adpn (EV^(PP-Adpn)) and control...
Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC
2 avr. 2026 02:00 - SFR Icat
Aberrant activation of the Wnt signaling pathway in triple-negative breast cancer (TNBC) is linked to treatment resistance and recurrence, yet its role in tumoral heterogeneity remains unclear. We developed Wnt reporter cell lines from two mesenchymal TNBC models (MDA-MB-231 and MDA-MB-436) using a Tcf/Lef-eGFP vector and observed intra- and inter-cellular variation in Wnt activity. Paired Wnt-positive and Wnt-negative TNBC cell lines were established and profiled by RNA-Seq. Integrative...
Comparison of Three Diagnostic Strategies for Suspicion of Pulmonary Embolism: Planar Ventilation-Perfusion Scan (V/Q), Computed Tomography Pulmonary Angiography (CTPA), and Single Photon Emission Computed Tomography Ventilation-Perfusion Scan (SPECT V/Q): a multicenter, non-inferiority randomised controlled trial
2 avr. 2026 02:00 - SFR Icat
CONCLUSION: After being prematurely discontinued, this randomised trial did not demonstrate the non-inferiority of a SPECT V/Q-based strategy to reference standards for PE diagnosis. However, the results suggest a low 3-month VTE risk in patients managed using a SPECT V/Q-based diagnostic strategy. Among patients with clinically suspected acute PE requiring chest imaging, a SPECT V/Q-based algorithm might be a reliable alternative in clinical practice.
Developing prognostic biomarkers for invasive fungal infections
2 avr. 2026 02:00 - SFR Icat
Invasive candidiasis is a severe fungal infection with management challenges due to a lack of biomarker-guided patient stratification and limited availability of antifungal drugs. Liu et al. identified the cytokine Meteorin-like as a key regulator and potential theranostic target, offering new hope for better diagnosis and treatment of these life-threatening infections.
Leadership delegation, team efficacy and resilience in critical care: a simulation-based study
31 mars 2026 02:00 - SFR Icat
CONCLUSIONS: Delegation in emergency teams was associated with team resilience rather than with clinical performance. Disruptive events led to leadership coming from other team members than the leaders.
Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies
30 mars 2026 02:00 - SFR Icat
Small nuclear RNAs (snRNAs) are essential components of the spliceosome. De novo variants in snRNA genes RNU4-2 (ReNU syndrome), RNU5B-1 and RNU2-2 have been linked to dominant neurodevelopmental disorders (NDDs), revealing a large unexpected contribution of noncoding RNA genes to genetic diseases. Here, through international collaborations, we analyze systematically 200 potentially functional snRNA genes in a French cohort of 34,329 people with rare disorders. We report RNU2-2 variants in 141...
Sex-specific cardiometabolic responses during microgravity simulation in European Space Agency VIVALDI dry immersion
30 mars 2026 02:00 - SFR Icat
CONCLUSIONS: These results establish dry immersion as a valuable tool for studying the physiological adaptations of astronauts to microgravity and understanding sex-specific responses, while providing a comprehensive control dataset for the development of future countermeasures.
Malignant transformation in patients with monoclonal gammopathy of undetermined significance treated with teriparatide for osteoporosis: a bicenter retrospective study and analysis of the French national pharmacovigilance database
29 mars 2026 01:00 - SFR Icat
CONCLUSION: Malignant progression was rare, providing reassuring evidence regarding hematologic safety. TPT may be considered in selected patients with severe osteoporosis and MGUS, provided careful hematologic monitoring.
Experiences of Migrants With Type 2 Diabetes Navigating Health Care in France: A Qualitative Study
28 mars 2026 01:00 - SFR Icat
CONCLUSION: Participants' care experiences were shaped by cultural habits, structural and administrative constraints, and limited health literacy. Nurses with their cultural competencies play a crucial role in care.
Clinical features and outcomes of fungal bone and joint infections in Western France
27 mars 2026 01:00 - SFR Icat
CONCLUSIONS: . Fungal BJIs represent a wide range of infections associated with a poor prognosis.
Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial
27 mars 2026 01:00 - SFR Icat
CONCLUSION: In patients with septic shock, hypothermia at inclusion and persistence of hypothermia during the first 24 h were associated with higher mortality at day 90. Mortality increased according to the course of hypothermia during the first 24 h, being highest in patients with persistent hypothermia, followed by those with transient hypothermia, and lowest in patients who never developed hypothermia.
Prognostic factors in interstitial lung disease-associated pulmonary hypertension: data from the HYPID cohort and the French Pulmonary Hypertension Registry
26 mars 2026 01:00 - SFR Icat
CONCLUSION: Non-invasive (6 MWD, WHO FC) and invasive (PVR) variables are associated with prognosis in patients with ILD-PH, including in patients with CPFE. PH medication might improve outcomes in this patient population.
Co-morbid insomnia and obstructive sleep apnea (COMISA) and cardiovascular risk: A scoping review
25 mars 2026 01:00 - SFR Icat
CONCLUSION: Although initial data suggest a potential synergistic effect of OSA and insomnia on CV risk, results remain mixed and limited by considerable methodological heterogeneity. Integrated management focusing on the multiple vulnerabilities of COMISA patients seems to be the most appropriate approach, regardless of a direct association with CV risk.
A decade of ocular fungal infections due to Penicillium-like fungi in France (2012 to 2021)
25 mars 2026 01:00 - SFR Icat
Penicillium, Talaromyces, and Purpureocillium species (so called Penicillium-like) are increasingly recognised as opportunistic fungal pathogens capable of causing a wide range of infections, from superficial to invasive. Although ocular infections caused by these environmental fungi have been reported in the literature, they remain relatively underrecognised. We conducted a multicentric retrospective study of Penicillium-like ocular cases reported in the RESSIF database of the French National...
Voacangine/coronaridine hydroxylases catalyze C19-hydroxylation in iboga alkaloid synthesis
23 mars 2026 01:00 - SFR Icat
The combination of bioinformatics and functional approaches was used to identify three cytochrome P450 from the CYP71 clan that perform the 19-hydroxylation of two monoterpene indole alkaloids (coronaridine and voacangine) from Voacanga thouarsii. Voacanga thouarsii is a medicinal plant from the Apocynaceae family producing monoterpene indole alkaloids (MIAs), notably iboga-type ones, to cope with their environment. Iboga MIAs, including ibogaine or voacristine, display a wide range of...