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Publications
Case Report: The role of bone scans in detecting Ribbing disease
27 mars 2025 01:00 - SFR Icat
In this case, we report the usefulness of bone scintigraphy in evaluating osteoarticular pain when the diagnosis is unclear after standard morphological imaging. A 24-year-old male patient exhibited mild left tibial pain that had been intensifying over a period of 2 years. The initial radiological evaluation suggested a diagnosis of pediatric tibial bone marrow osteosclerosis associated with periostitis, based on standard radiographs and MRI. However, a complementary bone scan was required for...
English Workshops with Simulated Patients and Peers Reduce Medical Students' Apprehension About Speaking in English
27 mars 2025 01:00 - SFR Icat
In this study, we evaluated workshops with simulated patients and peers to improve English-speaking confidence among medical students. Results showed reduced apprehension when interviewing patients, high course satisfaction, perceived progress in English proficiency, and increased confidence in future interactions with patients, supporting simulation-based methods in medical English education.
Cross-Analytical Strategies to Tackle "Medicines in Disguise" Presented as Food Supplements, a New Threat for Human Health
27 mars 2025 01:00 - SFR Icat
Plant-based food supplements (FS) of doubtful traceability have now emerged as a new threat to human health. Food supplements adulterated with pharmaceutical ingredients are considered "medicines in disguise" by regulatory authorities, which is a sub-category of falsified medicines. In the context of illegal manufacture and trade, as well as in the absence of an official phyto- and/or pharmacovigilance system, emergency departments and poison control centers constitute a early warning system for...
Clinical consequences of varenicline shortage: A study on the French national pharmacovigilance database
27 mars 2025 01:00 - SFR Icat
OBJECTIVES: Varenicline is a smoking cessation therapy included in the World Health Organization (WHO) model list of essential medicines. In May 2021, the presence of N-nitroso-varenicline, a carcinogenic agent, was detected in varenicline tablets above the limits determined by the European Medicine Agency (EMA), leading to batches being recalled and causing a shortage of this drug. The aim of this study was to use pharmacovigilance data to evaluate the clinical consequences of the shortage of...
Unraveling undiagnosed rare disease cases by HiFi long-read genome sequencing
26 mars 2025 01:00 - SFR Icat
Solve-RD is a pan-European rare disease (RD) research program that aims to identify disease-causing genetic variants in previously undiagnosed RD families. We utilized 10-fold coverage HiFi long-read sequencing (LRS) for detecting causative structural variants (SVs), single-nucleotide variants (SNVs), insertion-deletions (indels), and short tandem repeat (STR) expansions in previously studied RD families without a clear molecular diagnosis. Our cohort includes 293 individuals from 114...
Segmental corymbiform congenital melanocytic naevi: Implications for melanocytic embryology
26 mars 2025 01:00 - SFR Icat
No abstract
Identification of <em>Toxoplasma gondii</em> antigenic proteins using an <em>in vivo</em> approach and <em>in silico</em> investigation of their polymorphism
26 mars 2025 01:00 - SFR Icat
Toxoplasma gondii is a pathogen characterized by a large variety of strains whose virulence and clinical severity are likely linked to their genotype. Currently, the strains are genotyped using restriction fragment length polymorphism, multilocus sequence typing, and microsatellite markers. This typing requires the strain's DNA, which is difficult to obtain. A serotyping test could overcome the constraints of genotyping, the challenge being to identify type-specific proteins. We identified...
Heavy-Atom-Free Photosensitizer-Loaded Lipid Nanocapsules for Photodynamic Therapy
21 mars 2025 01:00 - SFR Icat
Photodynamic therapy (PDT) is a clinically approved noninvasive treatment for cancer that employs a photosensitizer (PS) to generate cytotoxic reactive singlet oxygen (ROS) species that precisely destroy cancer cells at the targeted tumor sites. There is growing interest in the development of innovative photosensitizing agents and advanced delivery methods, offering superior phototherapeutic performance. The delivery of PS is a challenging task in PDT in regard to the high hydrophobicity of the...
Dual-modality SEM-Raman smart scanning for fast hyperspectral Raman micro-imaging - application to bones
20 mars 2025 01:00 - SFR Icat
Recent works on smart scanning techniques in Raman micro-imaging demonstrate the possibility of highly reducing acquisition time. In particular, Gilet et al. [Optics Express32, 932 (2024)10.1364/OE.509736] proposed a protocol combining compression in both spectral and spatial domains by focusing on essential information. This protocol consists of a two-pass scan in Raman modality at different signal-to-noise ratios (SNR). The first scan of the entire sample area at low SNR, and was identified as...
Self-assemblies of cell-penetrating peptides and ferrocifens: design and biological evaluation of an innovative platform for lung cancer treatment
19 mars 2025 01:00 - SFR Icat
Chemotherapy, currently used for lung cancer treatment, often consists in a combination of drugs with a moderate efficacy and severe side effects. A major drawback of the classical inorganic drugs used is their hydrophobicity, leading to a very low blood availability and weak efficacy. To overcome this constraint, a nanoplatform was set up in order to vectorize a ferrocifen drug, an organometallic tamoxifen derivative known for its really potent in vitro activity, but as well for its poor water...
Innovative Trajectory Analysis Reveals Dynamics and Risk Factors of Post-Kidney Transplant Diabetes Mellitus in a French Cohort
19 mars 2025 01:00 - SFR Icat
CONCLUSION: This study confirmed the high prevalence and dynamic nature of PTDM after transplantation, emphasizing the critical role of pretransplant cardiovascular disease, BMI, and early post-transplant weight gain in the onset or remission of PTDM.
Extreme variability of vascular responses to slightly different abduction angles during abduction and external rotation tests, in patients with suspected thoracic outlet syndrome
18 mars 2025 01:00 - SFR Icat
Patients may not always perform a perfect 90° upper limb abduction when doing an abduction, external rotation test for the evaluation of thoracic outlet syndrome (TOS). We aimed to study the vascular responses to three slightly different abduction angles. Approach: We recorded fingertip arterial (A-PPG) and forearm venous (V-PPG) photo-plethysmography in 111 patients referred for suspicion or follow up of TOS. The measurements were made bilaterally during a 30 sec. surrender position,...
First environmental survey of <em>Scedosporium</em> species in Lebanon
18 mars 2025 01:00 - SFR Icat
CONCLUSION: These findings provide new insights into the ecology of Scedosporium species, bridging a gap in our knowledge of their distribution on the Asian continent and laying the groundwork for future clinical investigations. Future international collaborations are essential to trace the origin of S. apiospermum.
TRiP(cast) score and thrombosis risk for lower limb immobilisation - Authors' reply
15 mars 2025 01:00 - SFR Icat
No abstract
Antimicrobial activity of new anti-Pseudomonas beta-lactam-beta-lactamase inhibitors against Pseudomonas aeruginosa respiratory isolates recovered during the study for Monitoring Antimicrobial Resistance Trends (SMART) program in France (2016-2022)
15 mars 2025 01:00 - SFR Icat
CONCLUSION: C/T is a reliable treatment option in RTI caused by P. aeruginosa.
